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Levomefolic Acid

Name: Levomefolic Acid
Brand: TargetMol
SKU: T7094
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7094Cas No. 31690-09-2

Alias 5-MTHF

Levomefolic Acid (5-MTHF) is a natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. Levomefolinic acid is used as a treatment and to prevent Folate Deficiency

Levomefolic Acid

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Purity: 97.27%

Catalog No. T7094Alias 5-MTHFCas No. 31690-09-2

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	$50	In Stock	In Stock
50 mg	$100	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.27%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Levomefolic Acid AI Summary

Levomefolic Acid is a multi-functional compound that serves as a substrate for the TP transporter, exhibiting a Km value of 126,000.0 nM. It also acts as an inhibitor for DNP-SG uptake in bile canalicular membrane vesicles isolated from Sprague-Dawley rats, with a Ki value of 121,000.0 nM. Additionally, Levomefolic Acid inhibits the uptake of methotrexate (MTX) in OAT-K1-expressing MDCK cells, demonstrating a lower Ki value of 1,200.0 nM. Furthermore, this compound inhibits human HDAC6 enzyme activity, with an inhibition rate of 11.09% using a commercial peptide substrate and a slight activity decrease of -1.23% with a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Levomefolic Acid (5-MTHF) is a natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. Levomefolinic acid is used as a treatment and to prevent Folate Deficiency
Synonyms	5-MTHF

Chemical Properties

Molecular Weight	459.46
Formula	C₂₀H₂₅N₇O₆
Cas No.	31690-09-2
Smiles	CN1C(CNc2ccc(cc2)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CNc2[nH]c(N)nc(=O)c12
Relative Density.	1.62

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (43.53 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1765 mL	10.8823 mL	21.7647 mL	108.8234 mL
5 mM	0.4353 mL	2.1765 mL	4.3529 mL	21.7647 mL
10 mM	0.2176 mL	1.0882 mL	2.1765 mL	10.8823 mL
20 mM	0.1088 mL	0.5441 mL	1.0882 mL	5.4412 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc