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12-Hydroxydodecanoic acid

Name: 12-Hydroxydodecanoic acid
Brand: TargetMol
SKU: T4879
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4879Cas No. 505-95-3

Alias 12-hydroxylauric acid

12-Hydroxydodecanoic acid (12-hydroxylauric acid) is the substrate of the human glutathione-dependent formaldehyde dehydrogenase.

12-Hydroxydodecanoic acid

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Purity: 99.30%

Catalog No. T4879Alias 12-hydroxylauric acidCas No. 505-95-3

12-Hydroxydodecanoic acid (12-hydroxylauric acid) is the substrate of the human glutathione-dependent formaldehyde dehydrogenase.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$43	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.30%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

12-Hydroxydodecanoic acid AI Summary

12-Hydroxydodecanoic acid has agonist activity at the human GPR84 receptor, inducing [35S]GTPgammaS binding with an EC50 value of 20892.96 nM. However, its activity is considered weak, with a limited maximum effect (Emax = 27.0% in one assay and Emax = -17.0% in another) and modest inhibition of 5.0% at a 100 uM concentration. It does not exhibit significant agonist activity at the human FFA4 and FFA1 receptors, with EC50 values greater than 100000.0 nM in both assays, and shows low binding affinity in displacement studies (Ki > 10000.0 nM) on GPR84 receptors. Overall, 12-Hydroxydodecanoic acid demonstrates limited bioactivity as a GPR84 modulator..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	12-Hydroxydodecanoic acid (12-hydroxylauric acid) is the substrate of the human glutathione-dependent formaldehyde dehydrogenase.
Synonyms	12-hydroxylauric acid

Chemical Properties

Molecular Weight	216.32
Formula	C₁₂H₂₄O₃
Cas No.	505-95-3
Smiles	C(CCCCCCCCO)CCC(O)=O
Relative Density.	0.988g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (138.68 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6228 mL	23.1139 mL	46.2278 mL	231.1391 mL
5 mM	0.9246 mL	4.6228 mL	9.2456 mL	46.2278 mL
10 mM	0.4623 mL	2.3114 mL	4.6228 mL	23.1139 mL
20 mM	0.2311 mL	1.1557 mL	2.3114 mL	11.5570 mL
50 mM	0.0925 mL	0.4623 mL	0.9246 mL	4.6228 mL
100 mM	0.0462 mL	0.2311 mL	0.4623 mL	2.3114 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc