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Bendamustine
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Catalog No. T8380Cas No. 16506-27-7
Alias SDX105
Bendamustine (SDX105) for the treatment of Non-Hodgkin Lymphomas and Chronic Lymphocytic Leukemia
Bendamustine
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Purity: 99.99%
Catalog No. T8380Alias SDX105Cas No. 16506-27-7
Bendamustine (SDX105) for the treatment of Non-Hodgkin Lymphomas and Chronic Lymphocytic Leukemia
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $30 | In Stock | In Stock | |
| 5 mg | $67 | In Stock | In Stock | |
| 10 mg | $98 | In Stock | In Stock | |
| 25 mg | $179 | In Stock | In Stock | |
| 50 mg | $259 | In Stock | In Stock | |
| 100 mg | $372 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $75 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.99%
Appearance:Solid
Color:White
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Product Introduction
Bendamustine AI Summary
Bendamustine exhibits a variety of bioactivities with potent inhibitory actions against numerous targets, including GCN5L2, Histone Lysine Methyltransferase G9a, and various enzymes such as Histone Deacetylase (HDAC) and tyrosyl-DNA phosphodiesterase 1. It demonstrates significant cytotoxicity against several human cell lines, with IC50 values as low as 6980.0 nM for HL60 cells and greater than 92930.0 nM for A549 cells. The compound also shows inhibitory activity against the SARS-CoV-2 3CL-Pro protease by 78.33% at 20 µM, though it has limited efficacy in inhibiting SARS-CoV-2 in HRCE cells. It exhibits moderate distribution in the central nervous system of C57BL/6J mice with a serum half-life of 0.6667 hours and a CSF/serum AUC ratio of 35.0%. Additionally, it does not induce drug-induced liver injury in humans. The compound is active against various metalloenzymes due to its hydroxamic acid moiety, suggesting potential therapeutic applications in diseases involving these enzymes. Despite its multiple bioactivities, Bendamustine shows only moderate antiproliferative effects against some cancer cell lines, such as MDA-MB-231 and HeLa cells, and marginal antiviral activity against SARS-CoV-2..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Bendamustine (SDX105) for the treatment of Non-Hodgkin Lymphomas and Chronic Lymphocytic Leukemia |
| Synonyms | SDX105 |
| Molecular Weight | 358.26 |
| Formula | C16H21Cl2N3O2 |
| Cas No. | 16506-27-7 |
| Smiles | Cn1c(CCCC(O)=O)nc2cc(ccc12)N(CCCl)CCCl |
| Relative Density. | 1.31 g/cm3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 35 mg/mL (97.69 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.58 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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