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Anti-TLR2 Antibody-PE (3U29)
🥰Excellent
Catalog No. TMAY-00203P
Anti-TLR2 Antibody-PE (3U29) is a PE-conjugated Rabbit antibody targeting TLR2. Anti-TLR2 Antibody-PE (3U29) can be used in FCM.
Anti-TLR2 Antibody-PE (3U29)
Anti-TLR2 Antibody-PE (3U29)
🥰Excellent
Catalog No. TMAY-00203P
Anti-TLR2 Antibody-PE (3U29) is a PE-conjugated Rabbit antibody targeting TLR2. Anti-TLR2 Antibody-PE (3U29) can be used in FCM.
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Product Introduction
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Chemical Properties
| Description | Anti-TLR2 Antibody-PE (3U29) is a PE-conjugated Rabbit antibody targeting TLR2. Anti-TLR2 Antibody-PE (3U29) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 3U29 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human TLR2(CD282) expression on human whole blood monocytes. Cells were stained with PE-conjugated anti-Human TLR2(CD282). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable monocytes. |
| Application | FCM |
| Recommended Dose | 10 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human TLR2 / CD282 (rh TLR2 / CD282; NP_003255.2Met1-Arg587) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Research Background | TLR2, also known as CD282, is a member of the Toll-like receptor (TLR) family. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They play a fundamental role in pathogen recognition and activation of innate immunity. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR2 contains 14 LRR (leucine-rich) repeats and 1 TIR domain. TLR2 gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. CD282 cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. It also cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. CD282 acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. It may also promote apoptosis in response to lipoproteins. |
| Conjucates | PE |
| Others Formats | Unconjugated/APC/Biotin/FITC |
| Antibody Types Available | 5 |
| Immunogen | Recombinant Human TLR2 / CD282 Protein |
| Antigen Species | Human |
| Biology Area | Neuroinflammation |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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