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Prilocaine hydrochloride

Name: Prilocaine hydrochloride
Brand: TargetMol
SKU: T0796
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0796Cas No. 1786-81-8

Alias Xylonest, Propitocaine hydrochloride, Prilocaine HCl

Prilocaine hydrochloride (Prilocaine HCl) is a local anesthetic of the amino amide type, binds to voltage-gated sodium ion channels in the neuronal membrane, thereby preventing the permeability of sodium ions.

Prilocaine hydrochloride

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Purity: 99.97%

Catalog No. T0796Alias Xylonest, Propitocaine hydrochloride, Prilocaine HClCas No. 1786-81-8

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$30	In Stock	In Stock
500 mg	$68	In Stock	In Stock
1 g	$98	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.97%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Prilocaine hydrochloride AI Summary

Prilocaine hydrochloride exhibits a broad spectrum of biological activities. It shows significant antiplasmodial activity against Plasmodium falciparum GB4 with an IC50 of 12589.25 nM, and a potency range of 11220.2-14125.4 nM for inhibiting Plasmodium falciparum proliferation. Additionally, it demonstrates potent inhibition of various targets including Lamin A Splicing (25118.9 nM), Tau Fibril Formation (8912.5 nM), HPGD (19952.6 nM), Human alpha-Glucosidase (3981.1 nM), Lipid Storage Modulation (4466.8 nM), beta-arrestin-biased ligands of beta2-adrenergic receptor (3162.3 nM), Eya2 Phosphatase (22387.2 nM), and Histone Lysine Methyltransferase G9a (22.4 nM). It also exhibits inhibitory activity in OATP1B1- and OATP1B3-transfected CHO cells (87.24% and 74.6% inhibition at 10 uM, respectively). Despite showing low activity against SARS-CoV-2 in some assays, it has demonstrated inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 cells (-29.5% inhibition at 10 uM) and VERO-6 cells (0.16% inhibition at 10 uM). Prilocaine hydrochloride also inhibits the SARS-CoV-2 3CL-Pro protease by 14.97% at 20µM. Additionally, the compound exhibits antifungal activity against Candida albicans and antibacterial activity against multiple strains, including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, and MRSA Staphylococcus aureus. Prilocaine hydrochloride is a multifaceted molecule with potential applications in antiplasmodial, antiviral, antifungal, antibacterial therapies, and modulating various biological pathways..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Prilocaine hydrochloride (Prilocaine HCl) is a local anesthetic of the amino amide type, binds to voltage-gated sodium ion channels in the neuronal membrane, thereby preventing the permeability of sodium ions.
Synonyms	Xylonest, Propitocaine hydrochloride, Prilocaine HCl

Chemical Properties

Molecular Weight	256.77
Formula	C₁₃H₂₁ClN₂O
Cas No.	1786-81-8
Smiles	Cl.CCCNC(C)C(=O)Nc1ccccc1C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (233.67 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8945 mL	19.4727 mL	38.9454 mL	194.7268 mL
5 mM	0.7789 mL	3.8945 mL	7.7891 mL	38.9454 mL
10 mM	0.3895 mL	1.9473 mL	3.8945 mL	19.4727 mL
20 mM	0.1947 mL	0.9736 mL	1.9473 mL	9.7363 mL
50 mM	0.0779 mL	0.3895 mL	0.7789 mL	3.8945 mL
100 mM	0.0389 mL	0.1947 mL	0.3895 mL	1.9473 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc