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Anti-BRAF Monoclonal Antibody (3J215)
(Synonyms: RAFB1, FLJ95109, B-RAF1, BRAF1) Copy Product Info
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Synonyms: RAFB1, FLJ95109, B-RAF1, BRAF1
Catalog No. TMAT-0178 Copy Product Info
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Anti-BRAF Monoclonal Antibody (3J215) is a Mouse antibody targeting BRAF. Anti-BRAF Monoclonal Antibody (3J215) can be used in WB,IHC,IF.
Anti-BRAF Monoclonal Antibody
(3J215)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 20 µL | Inquiry | 7-10 days | 7-10 days | |
| 50 µL | Inquiry | 7-10 days | 7-10 days | |
| 100 µL | Inquiry | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
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| Description | Anti-BRAF Monoclonal Antibody (3J215) is a Mouse antibody targeting BRAF. Anti-BRAF Monoclonal Antibody (3J215) can be used in WB,IHC,IF. |
| Synonyms | RAFB1, FLJ95109, B-RAF1, BRAF1 |
| Ig Type | IgG1 |
| Clone | 3J215 |
| Reactivity | Human,Mouse |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; IHC: 1/200-1/1000; IF: 1/200-1/1000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/ml |
| Research Background | BRAF: v-raf murine sarcoma viral oncogene homolog B1, also known as BRAF1; RAFB1; B-RAF1; FLJ95109. Entrez Protein NP_004324. It is the main effectors recruited by GTP-bound Ras to activate the MEK-MAP kinase pathway. B-Raf contains three consensus Akt phosphorylationsites (Ser364, Ser428, and Thr439). B-Raf is a key regulatory molecule of the mitogen-activated protein kinase kinase (MEK), it has a long amino-terminal region,the region is essential for homo-dimerization of B-Raf and hetero-dimerization of B-Raf and c-Raf at the plasma membrane, followed by phosphorylation of Thr118 in the amino-terminal B-Raf-specific region. Notably, in calcium ionophore-stimulated HeLa cells, B-Raf could propagate signals to MEK under the basal level of GTP-Ras. Expression of Raf-B is highly restricted with highestlevels in the cerebrum and testes and defects in braf are involved in a wide range of cancers. The BRAF gene mutation is frequently detected in papillary thyroid carcinoma,melanocytic nevi, primary cutaneous melanomas and colorectal cancers. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human BRAF expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | BRAF |
| Gene ID | |
| Protein Name | Serine/threonine-protein kinase B-raf |
| Uniprot ID |
| Molecular Weight | Theoretical: 87 kDa |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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