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BIX02189

Name: BIX02189
Brand: TargetMol
SKU: T21295
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T21295Cas No. 1265916-41-3

Alias BIX 02189

BIX02189 is a potent and selective inhibitor of MEK5 and ERK5 (IC50: 1.5 nM and 59 nM).

BIX02189

🥰Excellent

Purity: 97.84%

Catalog No. T21295Alias BIX 02189Cas No. 1265916-41-3

BIX02189 is a potent and selective inhibitor of MEK5 and ERK5 (IC50: 1.5 nM and 59 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$29	In Stock	In Stock
5 mg	$46	In Stock	In Stock
10 mg	$68	In Stock	In Stock
25 mg	$128	In Stock	In Stock
50 mg	$221	In Stock	In Stock
100 mg	$329	In Stock	In Stock
200 mg	$475	-	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.84%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	BIX02189 is a potent and selective inhibitor of MEK5 and ERK5 (IC50: 1.5 nM and 59 nM).
Targets&IC50	RPS6KA6/RSK4:990 nM, ERK5:59 nM, RPS6KA3/RSK2:2.1 μM, FGFR1:1 μM, CSF1R (FMS):46 nM, JAK3:440 nM, MEK5:1.5 nM, Lck:250 nM, SRC:7.6 μM, MAPK14 (p38 alpha):3.7 μM, Abl-1:2.4 μM, c-Kit:1.1 μM, TGFβRI:580 nM
In vitro	BIX02189, which inhibited catalytic function of purified, MEK5 enzyme.?The MEK5 inhibitors blocked phosphorylation of ERK5, without affecting phosphorylation of ERK1/2 in sorbitol-stimulated HeLa cells.?The compounds also inhibited transcriptional activation of MEF2C, a downstream substrate of the MEK5/ERK5 signaling cascade, in a cellular trans-reporter assay system[1].
Synonyms	BIX 02189

Chemical Properties

Molecular Weight	440.54
Formula	C₂₇H₂₈N₄O₂
Cas No.	1265916-41-3
Smiles	CN(C)Cc1cccc(N\C(=C2/C(=O)Nc3cc(ccc23)C(=O)N(C)C)c2ccccc2)c1
Relative Density.	1.230 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 49.4 mg/mL (112.14 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.54 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2699 mL	11.3497 mL	22.6994 mL	113.4971 mL
5 mM	0.4540 mL	2.2699 mL	4.5399 mL	22.6994 mL
10 mM	0.2270 mL	1.1350 mL	2.2699 mL	11.3497 mL
20 mM	0.1135 mL	0.5675 mL	1.1350 mL	5.6749 mL
50 mM	0.0454 mL	0.2270 mL	0.4540 mL	2.2699 mL
100 mM	0.0227 mL	0.1135 mL	0.2270 mL	1.1350 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc