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GW590735

Name: GW590735
Brand: TargetMol
SKU: T9766
Price: 87 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9766Cas No. 343321-96-0

GW590735 is an effective and selective PPARα agonist with an EC50 of 4 nM on PPARα and at least 500-fold selectivity versus PPARδ and PPARγ. GW590735 can be used in dyslipidemia studies.

GW590735

🥰Excellent

Purity: 99.53%

Catalog No. T9766Cas No. 343321-96-0

GW590735 is an effective and selective PPARα agonist with an EC50 of 4 nM on PPARα and at least 500-fold selectivity versus PPARδ and PPARγ. GW590735 can be used in dyslipidemia studies.

Pack Size	Price	Availability
1 mg	$87	In Stock
5 mg	$213	In Stock
10 mg	$313	In Stock
25 mg	$533	In Stock
50 mg	$768	In Stock
100 mg	$1,080	In Stock
1 mL x 10 mM (in DMSO)	$225	In Stock

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Purity:99.53%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	GW590735 is an effective and selective PPARα agonist with an EC50 of 4 nM on PPARα and at least 500-fold selectivity versus PPARδ and PPARγ. GW590735 can be used in dyslipidemia studies.
In vivo	GW590735 (2 mg/kg; i.v.) shows Cl, Vd, T1/2, and F% are 13 mL/min/kg, 2.8 L/kg, 2.6 hours and 85%, respectively in dogs while GW590735 (2.7 mg/kg; i.v.) shows Cl, Vd, T1/2, and F% are 5 mL/min/kg, 1 L/kg, 2.4 hours and 47%, respectively in rats. In male C

Chemical Properties

Molecular Weight	478.48
Formula	C₂₃H₂₁F₃N₂O₄S
Cas No.	343321-96-0
Smiles	Cc1nc(sc1C(=O)NCc1ccc(OC(C)(C)C(O)=O)cc1)-c1ccc(cc1)C(F)(F)F
Relative Density.	1.342 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (104.5 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0900 mL	10.4498 mL	20.8995 mL	104.4976 mL
5 mM	0.4180 mL	2.0900 mL	4.1799 mL	20.8995 mL
10 mM	0.2090 mL	1.0450 mL	2.0900 mL	10.4498 mL
20 mM	0.1045 mL	0.5225 mL	1.0450 mL	5.2249 mL
50 mM	0.0418 mL	0.2090 mL	0.4180 mL	2.0900 mL
100 mM	0.0209 mL	0.1045 mL	0.2090 mL	1.0450 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc