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Trigonelline
🥰Excellent
Catalog No. T2887Cas No. 535-83-1
Alias Trigenolline
Trigonelline (Trigenolline), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.
Trigonelline
🥰Excellent
Purity: 99.49%
Catalog No. T2887Alias TrigenollineCas No. 535-83-1
Trigonelline (Trigenolline), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $33 | In Stock | |
| 10 mg | $55 | In Stock | |
| 25 mg | $90 | In Stock | |
| 50 mg | $128 | In Stock | |
| 100 mg | $172 | In Stock |
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Purity:99.49%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Trigonelline (Trigenolline), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee. |
| In vitro | Treatment of cells with Trigonelline attenuates H2O2 induced cell deaths and improves the antioxidant activity. In addition, Trigonelline regulates the apoptotic gene caspase-3, caspase-9, and anti-apoptotic gene Bcl-2, Bcl-XL during H2O2 induced oxidative stress in H9c2 cells. Trigonelline significantly reduces the H2O2 induced necrosis and apoptosis in H9c2 cells. However, the further increment of Trigonelline concentration against H2O2 can induce the necrosis and apoptosis along with H2O2[1]. |
| In vivo | Trigonelline decreases bone mineralization and tends to worsen bone mechanical properties in streptozotocin-induced diabetic rats. Trigonelline significantly increases bone mineral density (BMD) and tends to improve cancellous bone strength in nicotinamide/streptozotocin-treated rats. Trigonelline differentially affects the skeletal system of rats with streptozotocin-induced metabolic disorders like intensify the osteoporotic changes in streptozotocin-treated rats and favorably affect bones in the non-hyperglycemic (nicotinamide/streptozotocin-treated) rats[2]. |
| Synonyms | Trigenolline |
| Molecular Weight | 137.14 |
| Formula | C7H7NO2 |
| Cas No. | 535-83-1 |
| Smiles | C[n+]1cccc(c1)C([O-])=O |
| Relative Density. | 1.2528 g/cm3 (Estimated) |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 27.78 mg/mL (202.57 mM), Sonication is recommended.  DMSO: 7.5 mg/mL (54.69 mM), Sonication is recommended. Ethanol: Insoluble | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/H2O
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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