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Trigonelline

Name: Trigonelline
Brand: TargetMol
SKU: T2887
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2887Cas No. 535-83-1

Alias Trigenolline

Trigonelline (Trigenolline), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.

Trigonelline

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Purity: 99.49%

Catalog No. T2887Alias TrigenollineCas No. 535-83-1

Trigonelline (Trigenolline), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$33	In Stock	In Stock
10 mg	$55	In Stock	In Stock
25 mg	$90	In Stock	In Stock
50 mg	$128	In Stock	In Stock
100 mg	$172	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.49%

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Trigonelline (Trigenolline), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.
In vitro	Treatment of cells with Trigonelline attenuates H2O2 induced cell deaths and improves the antioxidant activity. In addition, Trigonelline regulates the apoptotic gene caspase-3, caspase-9, and anti-apoptotic gene Bcl-2, Bcl-XL during H2O2 induced oxidative stress in H9c2 cells. Trigonelline significantly reduces the H2O2 induced necrosis and apoptosis in H9c2 cells. However, the further increment of Trigonelline concentration against H2O2 can induce the necrosis and apoptosis along with H2O2[1].
In vivo	Trigonelline decreases bone mineralization and tends to worsen bone mechanical properties in streptozotocin-induced diabetic rats. Trigonelline significantly increases bone mineral density (BMD) and tends to improve cancellous bone strength in nicotinamide/streptozotocin-treated rats. Trigonelline differentially affects the skeletal system of rats with streptozotocin-induced metabolic disorders like intensify the osteoporotic changes in streptozotocin-treated rats and favorably affect bones in the non-hyperglycemic (nicotinamide/streptozotocin-treated) rats[2].
Synonyms	Trigenolline

Chemical Properties

Molecular Weight	137.14
Formula	C₇H₇NO₂
Cas No.	535-83-1
Smiles	C[n+]1cccc(c1)C([O-])=O
Relative Density.	1.2528 g/cm3 (Estimated)

Storage & Solubility Information

Storage

keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 27.78 mg/mL (202.57 mM), Sonication is recommended.

DMSO: 7.5 mg/mL (54.69 mM), Sonication is recommended.

Ethanol: Insoluble

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	7.2918 mL	36.4591 mL	72.9182 mL	364.5909 mL
5 mM	1.4584 mL	7.2918 mL	14.5836 mL	72.9182 mL
10 mM	0.7292 mL	3.6459 mL	7.2918 mL	36.4591 mL
20 mM	0.3646 mL	1.8230 mL	3.6459 mL	18.2295 mL
50 mM	0.1458 mL	0.7292 mL	1.4584 mL	7.2918 mL

H2O

	1mg	5mg	10mg	50mg
100 mM	0.0729 mL	0.3646 mL	0.7292 mL	3.6459 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc