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TargetMol | Compound Library

Anti-Breast Cancer Compound Library

Catalog No. L2191

Breast cancer is an uncontrolled growth of breast cells. Among women, breast cancer is the second most common cancer diagnosed, after skin cancer (, and the second leading cause of cancer death, after lung cancer. In recent years, incidence rates have increased slightly (by 0.3% per year). There are several types of breast cancer, and they are broken into two main categories: noninvasive or in situ (ductal or lobular), and invasive (ductal or lobular). In addition, breast cancer can be categorized into four molecular subtypes: a "basal-like" subgroup with low estrogen receptor (ER)/progesterone receptor (PR)/human epidermal growth factor receptor 2 (HER2) and expression of basal cytokeratins (ER-PR-HER2-); a subgroup mainly driven by HER2 amplification and overexpression while being ER/PR low (ER-PR-HER2+); a luminal A group with high ER/PR and low HER2 (ER+PR+HER2-); a luminal B group with high ER/HER2 and low PR (ER+PR-HER2+). Depending on the caner's stage and molecular type, treatment options and prognostics of breast cancers are different: a combination of surgery, radiation therapy, chemotherapy, hormone therapy and/or administration of a targeted therapy (anti-HER2) or non-HER2 targeted therapy. Several potential targets for new breast cancer drugs have been identified in recent years. Drugs based on these targets, such as kinase inhibitors (AKT), and PD-L1, are now being studied to treat triple-negative breast cancers, either by themselves, or in combination with chemotherapy. TargetMol's Anti-Breast Cancer Compound Library collects 2440 compounds related to breast cancer, including all reported compounds with anti-breast cancer therapeutic effect, and compounds targeting related targets in signaling pathway (HER-2, VEGF, EGFR, PARP, CDK4/6, HSP, PD-1, SET7/9, BRCA, etc.). It is a power tool for breast cancer drug discovery.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L2191

Anti-Breast Cancer Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

Product Description Product Description

  • A unique collection of 2440 compounds with anti-breast cancer therapeutic activity or targeting breast cancer’s major signaling pathways, can be used for anti-breast cancer drug discovery and mechanism study;
  • Targets include HER-2, VEGF, EGFR, PARP, CDK4/6, HSP, PD-1, SET7/9, BRCA, etc.;
  • Some compounds have been in market or in clinical trials;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC validated to ensure high purity and quality.

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Apoptosis
Autophagy
NF-κB
PI3K
EGFR
CDK
VEGFR
Reactive Oxygen Species
COX
Endogenous Metabolite
mTOR
Akt
PPAR
HDAC
PARP
Antibacterial
AMPK
FGFR
GSK-3
HSP
TGF-beta/Smad
PDGFR
ERK
FLT
Parasite
Estrogen/progestogen Receptor
c-Kit
Estrogen Receptor/ERR
Src
IκB/IKK
Caspase
DNA/RNA Synthesis
p38 MAPK
TNF
DNA-PK
Wnt/beta-catenin
Cytochromes P450
S6 Kinase
STAT
Bcl-2 Family
Ferroptosis
ATM/ATR
c-Met/HGFR
HIV Protease
HER
Progesterone Receptor
Antioxidant
Antibiotic
JNK
Microtubule Associated
PKC
ALK
Calcium Channel
RIP kinase
Aurora Kinase
Influenza Virus
Antifungal
Gamma-secretase
IL Receptor
Ras
NO Synthase
PDK
Mitophagy
NOD
Potassium Channel
Bcr-Abl
Dehydrogenase
Raf
PD-1/PD-L1
MMP
JAK
c-RET
Topoisomerase
MEK
PKA
Interleukin
Virus Protease
NOD-like Receptor (NLR)
IRAK
MAPK
HIF/HIF Prolyl-Hydroxylase
IGF-1R
Lipoxygenase
ROS
PI4K
Phosphatase
Drug Metabolite
Casein Kinase
Beta Amyloid
Chk
NOS
Prostaglandin Receptor
p53
Tyrosine Kinases
Nrf2
FAK
GABA Receptor
Mitochondrial Metabolism
c-Fms
TAM Receptor
Epigenetic Reader Domain
HSV
PDE
Tyrosinase
Androgen Receptor
P-gp
TLR
TRP/TRPV Channel
MDM-2/p53
Sodium Channel
Trk receptor
Sirtuin
HCV Protease
PTEN
Aromatase
Syk
SIK
AChR
PROTACs
ROCK
Proteasome
Tie-2
Cholinesterase (ChE)
Glutathione Peroxidase
Aryl Hydrocarbon Receptor
Histone Methyltransferase
PGE Synthase
transporter
5-HT Receptor
Anti-infection
DYRK
c-Myc
PLK
Integrin
Glucosidase
SARS-CoV
ATPase
Carbonic Anhydrase
Histone Demethylase
Nucleoside Antimetabolite/Analog
Serine/threonin kinase
Opioid Receptor
Cannabinoid Receptor
NADPH
Adrenergic Receptor
Antiviral
SGK
GPCR
MELK
HIF
Serine Protease
IAP
E1/E2/E3 Enzyme
OXPHOS
Fatty Acid Synthase
Pim
Glucocorticoid Receptor
CaMK
Adenosine Receptor
Angiotensin-converting Enzyme (ACE)
DUB
Reductase
RAAS
Histamine Receptor
CSF-1R
Hedgehog/Smoothened
Phospholipase
Chloride channel
Leukotriene Receptor
LDL
Free radical scavengers
FKBP
Retinoid Receptor
MLK
PYK2
Antifection
Survivin
Transferase
ADC Cytotoxin
Rho
MAO
Ephrin Receptor
ROS Kinase
BTK
ROR
S1P Receptor
DHFR
DNA Alkylation
PERK
HBV
FAAH
GluR
IRE1
LRRK2
MRP
Wee1
BCRP
BACE
RANKL/RANK
Molecular Glues
AhR
GTPase
GNRH Receptor
Histone Acetyltransferase
PAI-1
Reverse Transcriptase
Immunology/Inflammation related
MNK
RSV
TOPK
Cholecystokinin Receptor
Myosin
Beta-Secretase
LTR
ABC Transporter
CCR
ATP Citrate Lyase
CFTR
RAR/RXR
MyD88
DNA Alkylator/Crosslinker
Cysteine Protease
FXR
Prolyl Endopeptidase (PREP)
CXCR
STING
GPX
Dopamine Receptor
Antifolate
Glutaminase
Indoleamine 2,3-Dioxygenase (IDO)
Aminopeptidase
Discoidin Domain Receptor (DDR)
Kinesin
YAP
IFNAR
IDO
Monoamine Oxidase
Mdm2
cAMP
Gap Junction Protein
Amino Acids and Derivatives
Ligands for Target Protein for PROTAC
Lipase
Cell Cycle Arrest
Glucokinase
PAFR
Haspin Kinase
NMDAR
Hexokinase
Target Protein Ligand-Linker Conjugate
NPC1L1
AAK1
Serotonin Transporter
LDLR
FLAP
Smo
Endothelin Receptor
Glutathione reductase
Acyltransferase
Decarboxylase
Ligand for E3 Ligase
Adenosine Deaminase
APC/C
CD38
NR4A
PROTAC Linker
DNA
cGAS
KRas
CRISPR/Cas9
Proton pump
Melatonin Receptor
DNA gyrase
Epoxide Hydrolase
Pyroptosis
NADPH-oxidase
PKM
LPL Receptor
MIF
UGT
Somatostatin
Cuproptosis
DAPK
Protease-activated Receptor
NUDIX hydrolase
Necroptosis
OCT
Hck
GRK
Na-K-Cl cotransporter
ACK1
Telomerase
SGLT
HuR
DNA Methyltransferase
Thrombin
Y Box Binding Protein 1
gp120/CD4
ASCT
Photosensitizer
Liver X Receptor
PAK
AIM2
GST
Platelet aggregation
Vitamin

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