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TargetMol | Compound Library

Anti-Breast Cancer Compound Library

Catalog No. L2191

Breast cancer is an uncontrolled growth of breast cells. Among women, breast cancer is the second most common cancer diagnosed, after skin cancer (, and the second leading cause of cancer death, after lung cancer. In recent years, incidence rates have increased slightly (by 0.3% per year). There are several types of breast cancer, and they are broken into two main categories: noninvasive or in situ (ductal or lobular), and invasive (ductal or lobular). In addition, breast cancer can be categorized into four molecular subtypes: a "basal-like" subgroup with low estrogen receptor (ER)/progesterone receptor (PR)/human epidermal growth factor receptor 2 (HER2) and expression of basal cytokeratins (ER-PR-HER2-); a subgroup mainly driven by HER2 amplification and overexpression while being ER/PR low (ER-PR-HER2+); a luminal A group with high ER/PR and low HER2 (ER+PR+HER2-); a luminal B group with high ER/HER2 and low PR (ER+PR-HER2+). Depending on the caner's stage and molecular type, treatment options and prognostics of breast cancers are different: a combination of surgery, radiation therapy, chemotherapy, hormone therapy and/or administration of a targeted therapy (anti-HER2) or non-HER2 targeted therapy. Several potential targets for new breast cancer drugs have been identified in recent years. Drugs based on these targets, such as kinase inhibitors (AKT), and PD-L1, are now being studied to treat triple-negative breast cancers, either by themselves, or in combination with chemotherapy. TargetMol's Anti-Breast Cancer Compound Library collects 2440 compounds related to breast cancer, including all reported compounds with anti-breast cancer therapeutic effect, and compounds targeting related targets in signaling pathway (HER-2, VEGF, EGFR, PARP, CDK4/6, HSP, PD-1, SET7/9, BRCA, etc.). It is a power tool for breast cancer drug discovery.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L2191

Anti-Breast Cancer Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

Product Description Product Description

  • A unique collection of 2440 compounds with anti-breast cancer therapeutic activity or targeting breast cancer’s major signaling pathways, can be used for anti-breast cancer drug discovery and mechanism study;
  • Targets include HER-2, VEGF, EGFR, PARP, CDK4/6, HSP, PD-1, SET7/9, BRCA, etc.;
  • Some compounds have been in market or in clinical trials;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC validated to ensure high purity and quality.

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Apoptosis
Autophagy
NF-κB
PI3K
EGFR
CDK
VEGFR
Reactive Oxygen Species
COX
mTOR
PPAR
Akt
Endogenous Metabolite
HDAC
PARP
AMPK
FGFR
GSK-3
Antibacterial
HSP
PDGFR
TGF-beta/Smad
ERK
FLT
c-Kit
Estrogen/progestogen Receptor
Estrogen Receptor/ERR
Src
IκB/IKK
DNA-PK
TNF
DNA/RNA Synthesis
Parasite
STAT
p38 MAPK
S6 Kinase
Wnt/beta-catenin
ATM/ATR
HER
Progesterone Receptor
Antioxidant
Caspase
HIV Protease
Ferroptosis
ALK
c-Met/HGFR
Antibiotic
Aurora Kinase
IL Receptor
JNK
Microtubule Associated
RIP kinase
PDK
PKC
Calcium Channel
Cytochromes P450
Gamma-secretase
Influenza Virus
NOD
Mitophagy
Potassium Channel
Bcr-Abl
PD-1/PD-L1
c-RET
JAK
Topoisomerase
Antifungal
Bcl-2 Family
IRAK
MEK
NO Synthase
Raf
Lipoxygenase
PKA
ROS
Dehydrogenase
IGF-1R
MAPK
PI4K
Chk
MMP
NOS
p53
Nrf2
Prostaglandin Receptor
Beta Amyloid
Casein Kinase
NOD-like Receptor (NLR)
TAM Receptor
Virus Protease
Epigenetic Reader Domain
FAK
Mitochondrial Metabolism
PDE
Phosphatase
Tyrosinase
Tyrosine Kinases
Androgen Receptor
c-Fms
GABA Receptor
HIF/HIF Prolyl-Hydroxylase
Aromatase
HSV
Interleukin
Sirtuin
Sodium Channel
Drug Metabolite
HCV Protease
Ras
SIK
Syk
TLR
Trk receptor
TRP/TRPV Channel
5-HT Receptor
AChR
P-gp
PROTACs
PTEN
ROCK
transporter
Adrenergic Receptor
Antiviral
Carbonic Anhydrase
DYRK
GPCR
HIF
Histone Demethylase
Histone Methyltransferase
MELK
NADPH
Nucleoside Antimetabolite/Analog
PGE Synthase
PLK
Proteasome
Serine/threonin kinase
Adenosine Receptor
Anti-infection
Cannabinoid Receptor
Cholinesterase (ChE)
E1/E2/E3 Enzyme
Glucocorticoid Receptor
Integrin
Opioid Receptor
Pim
Serine Protease
SGK
ADC Cytotoxin
Antifection
Aryl Hydrocarbon Receptor
ATPase
CaMK
Chloride channel
CSF-1R
Ephrin Receptor
Fatty Acid Synthase
Free radical scavengers
Glucosidase
Glutathione Peroxidase
Hedgehog/Smoothened
Histamine Receptor
IAP
LDL
MAO
MLK
PYK2
RAAS
Rho
SARS-CoV
Tie-2
Transferase
AhR
BACE
BCRP
DHFR
DNA Alkylation
DUB
GluR
GNRH Receptor
GTPase
HBV
IRE1
Kinesin
Leukotriene Receptor
LRRK2
MRP
Phospholipase
Retinoid Receptor
ROR
S1P Receptor
Survivin
Wee1
BTK
ABC Transporter
Antifolate
Beta-Secretase
cAMP
CCR
Cholecystokinin Receptor
c-Myc
CXCR
Cysteine Protease
Discoidin Domain Receptor (DDR)
DNA Alkylator/Crosslinker
Dopamine Receptor
FAAH
Gap Junction Protein
Glutaminase
GPX
IFNAR
Immunology/Inflammation related
Indoleamine 2,3-Dioxygenase (IDO)
LTR
Mdm2
MNK
PAI-1
PERK
RANKL/RANK
RAR/RXR
Reverse Transcriptase
RSV
STING
TOPK
YAP
AAK1
ACK1
Acyltransferase
Adenosine Deaminase
Aminopeptidase
APC/C
ATP Citrate Lyase
Cell Cycle Arrest
CFTR
cGAS
CRISPR/Cas9
DAPK
Decarboxylase
DNA
DNA gyrase
DNA Methyltransferase
Endothelin Receptor
FLAP
FXR
Glucokinase
Glutathione reductase
gp120/CD4
GRK
GST
Haspin Kinase
Hck
Hexokinase
Histone Acetyltransferase
HuR
KSP
Ligand for E3 Ligase
Lipase
Liver X Receptor
LPL Receptor
Melatonin Receptor
Monoamine Oxidase
MyD88
Myosin
NADPH-oxidase
NMDAR
NPC1L1
NUDIX hydrolase
OCT
OXPHOS
PAFR
PAK
PKM
Platelet aggregation
PROTAC Linker
Protease-activated Receptor
Proton pump
Reductase
ROS Kinase
SGLT
Smo
Somatostatin
Telomerase
Thrombin
UGT

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