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Ag85B Protein, Mycobacterium tuberculosis, Recombinant (E. coli, His)

Catalog No. TMPH-03005
Synonyms: 30 kDa extracellular protein, DGAT, Fbps B, Diacylglycerol acyltransferase/mycolyltransferase Ag85B, Antigen 85 complex B, Extracellular alpha-antigen, Fibronectin-binding protein B, Acyl-CoA:diacylglycerol acyltransferase

The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan and through the synthesis of alpha,alpha-trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) to another TMM, leading to the formation of TDM.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Ag85B Protein, Mycobacterium tuberculosis, Recombinant (E. coli, His)
Pack Size Availability Price/USD Quantity
20 μg 20 days $ 360.00
100 μg 20 days $ 678.00
1 mg 20 days $ 2,300.00
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Biological Description
Technical Params
Product Properties
Description The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan and through the synthesis of alpha,alpha-trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) to another TMM, leading to the formation of TDM.
Species Mycobacterium tuberculosis
Expression System E. coli
Tag N-terminal 6xHis-tagged
Accession Number P9WQP0
Synonyms 30 kDa extracellular protein, DGAT, Fbps B, Diacylglycerol acyltransferase/mycolyltransferase Ag85B, Antigen 85 complex B, Extracellular alpha-antigen, Fibronectin-binding protein B, Acyl-CoA:diacylglycerol acyltransferase
Amino Acid FSRPGLPVEYLQVPSPSMGRDIKVQFQSGGNNSPAVYLLDGLRAQDDYNGWDINTPAFEWYYQSGLSIVMPVGGQSSFYSDWYSPACGKAGCQTYKWETFLTSELPQWLSANRAVKPTGSAAIGLSMAGSSAMILAAYHPQQFIYAGSLSALLDPSQGMGPSLIGLAMGDAGGYKAADMWGPSSDPAWERNDPTQQIPKLVANNTRLWVYCGNGTPNELGGANIPAEFLENFVRSSNLKFQDAYNAAGGHNAVFNFPPNGTHSWEYWGAQLNAMKGDLQSSLGAG Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Construction 41-325 aa
Protein Purity > 85% as determined by SDS-PAGE.
Molecular Weight 36.2 kDa (predicted)
Formulation Tris-based buffer,50% glycerol
Reconstitution A hardcopy of COA with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Stability & Storage

Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan and through the synthesis of alpha,alpha-trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) to another TMM, leading to the formation of TDM.

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Keywords

Ag85B Protein, Mycobacterium tuberculosis, Recombinant (E. coli, His) 30 kDa extracellular protein DGAT Fbps B Diacylglycerol acyltransferase/mycolyltransferase Ag85B Antigen 85 complex B Extracellular alpha-antigen Fibronectin-binding protein B Acyl-CoA:diacylglycerol acyltransferase recombinant recombinant-proteins proteins protein

 

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