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D-Valine

Name: D-Valine
Brand: TargetMol
SKU: T9298
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9298Cas No. 640-68-6

Alias Valine, D-, H-D-Val-OH, (R)-Valine

D-Valine (H-D-Val-OH) is the enantiomer of L-Valine.

D-Valine

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Purity: 99.93%

Catalog No. T9298Alias Valine, D-, H-D-Val-OH, (R)-ValineCas No. 640-68-6

D-Valine (H-D-Val-OH) is the enantiomer of L-Valine.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$30	-	In Stock
10 g	$38	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.93%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

D-Valine AI Summary

D-Valine shows bioactivity across multiple assays and targets. It demonstrates potency of 19952.6 nM in a Modulators of Lamin A Splicing assay and 2511.9 nM in an assay for blocking the interaction between CBF-beta and RUNX1, relevant for Acute Myeloid Leukemia treatment. Additionally, it inhibits human PAT1-mediated L-[3H]proline uptake in Caco2 cells with a Ki value of 100000000.0 nM and a pKi value of -2.0 mM. It also inhibits L-[3H]-gabapentin uptake via human LAT1 in TREx HEK293 cells by 11.0% at 200 uM, and induces efflux of [3H]-gabapentin with 41.0% activity at the same concentration. The compound exhibits antiviral activity against SARS-CoV-2, inhibiting virus-induced cytotoxicity in Caco-2 cells at 10 µM concentration after 48 hours by 0.22%, and showing 16.0% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM. Additionally, it inhibits SARS-CoV-2 induced cytotoxicity in VERO-6 cells at 10 uM concentration after 48 hours, with IC50 values exceeding 20000.0 nM and 19952.62 nM. Moreover, D-Valine displays inhibition activity in enzymatic assays of human HDAC6, with a -33.4% inhibition using a commercial peptide substrate and 1.7% inhibition with a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	D-Valine (H-D-Val-OH) is the enantiomer of L-Valine.
Synonyms	Valine, D-, H-D-Val-OH, (R)-Valine

Chemical Properties

Molecular Weight	117.15
Formula	C₅H₁₁NO₂
Cas No.	640-68-6
Smiles	CC(C)[C@@H](N)C(O)=O
Relative Density.	1.2000 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: < 1.17 mg/mL (10 mM, insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	8.5361 mL	42.6803 mL	85.3606 mL	426.8032 mL
5 mM	1.7072 mL	8.5361 mL	17.0721 mL	85.3606 mL
10 mM	0.8536 mL	4.2680 mL	8.5361 mL	42.6803 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc