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Anti-CD146/MCAM Antibody (2I373)
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Catalog No. TMAY-00292
Alias MUC18, melanoma cell adhesion molecule, CD146
Anti-CD146/MCAM Antibody (2I373) is a Mouse antibody targeting CD146/MCAM. Anti-CD146/MCAM Antibody (2I373) can be used in ELISA,ELISA(Cap).
Anti-CD146/MCAM Antibody (2I373)
Anti-CD146/MCAM Antibody (2I373)
😃Good
Catalog No. TMAY-00292Alias MUC18, melanoma cell adhesion molecule, CD146
Anti-CD146/MCAM Antibody (2I373) is a Mouse antibody targeting CD146/MCAM. Anti-CD146/MCAM Antibody (2I373) can be used in ELISA,ELISA(Cap).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $68 | 7-10 days | |
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CD146/MCAM Antibody (2I373) is a Mouse antibody targeting CD146/MCAM. Anti-CD146/MCAM Antibody (2I373) can be used in ELISA,ELISA(Cap). |
| Alias | MUC18, melanoma cell adhesion molecule, CD146 |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 2I373 |
| Reactivity | Human |
| Application | ELISA,ELISA(Cap) |
| Recommended Dose | ELISA: 1:1000-1:2000; ELISA(Cap): 1:250-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD146 / MCAM extracellular domain (rh CD146; TMPY-01034; NP_006491.2; Met 1-Gly 559). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | The CD146 antigen, also known as melanoma cell adhesion molecule (MCAM) and MUC18, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 contains the characteristic immunoglobulin-like domains (V-V-C2-C2-C2), a transmembrane region, and a short cytoplasmic tail. The CD146 expression is detected in endothelial cells in vascular tissue throughout the body and plays a role in cell adhesion, as well as in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. As a Ca2+-independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor, CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis, or immune recognition. This protein is also expressed predominantly on metastatic lesions and advanced primary tumors, and thus has been suggested to play an important role in tumor progression and the development of metastasis in certain human carcinomas. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human CD146 protein (TMPY-01034) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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