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Veratric acid

Name: Veratric acid
Brand: TargetMol
SKU: T3744
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3744Cas No. 93-07-2

Alias Veratrumenoic acid, 3,4-Dimethoxybenzoic acid

Veratric acid (3,4-Dimethoxybenzoic acid) is a benzoic acid derivative from plants and fruits, possessing antioxidant, anti-inflammatory, and blood pressure-lowering properties.

Veratric acid

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Purity: 99.44%

Catalog No. T3744Alias Veratrumenoic acid, 3,4-Dimethoxybenzoic acidCas No. 93-07-2

Veratric acid (3,4-Dimethoxybenzoic acid) is a benzoic acid derivative from plants and fruits, possessing antioxidant, anti-inflammatory, and blood pressure-lowering properties.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.44%

Appearance:Solid

Color:White

Resource Download

COA LCMS HPLC HNMR

Product Introduction

Veratric acid AI Summary

Veratric acid demonstrates a broad spectrum of bioactivities. It inhibits purified human kidney thiopurine methyltransferase (TPMT) with an IC50 of 100,000.0 nM and human carbonic anhydrases 1, 2, 9, 12, 4, 6, 14, and 7 with Ki values ranging from 6180.0 nM to 24420.0 nM. The compound also exhibits antibacterial and antifungal properties, showing activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Candida albicans, and Aspergillus niger with MIC values between 9.0 µg/mL and 18.0 µg/mL and corresponding -logMIC values ranging from 1.01 to 1.31. Additionally, Veratric acid is a potent nematicide against Heterodera zeae larvae, achieving mortality rates up to 100% at a 1% concentration under light conditions. It also exhibits antifeedant activity against Hylobius abietis with an AFI of 7.0% at 50 mM concentration. In various other assays, it has shown inhibitory effects on TGF-β with a potency of 35481.3 nM, and on binding/entry for Marburg Virus with a potency of 398.1 nM. It significantly inhibits sodium fluorescein uptake in OATP1B3 and OATP1B1 transfected CHO cells, demonstrating approximately 107% and 111% inhibition respectively at 10 µM concentration. It slightly inhibits mushroom tyrosinase activity and shows very low antioxidant activity. Furthermore, it inhibits human TAS2R39 when expressed in HEK293 cells coexpressing G-protein at 10 mM concentration, reducing epicatechin gallate-induced intracellular calcium release by 10.0%..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Veratric acid (3,4-Dimethoxybenzoic acid) is a benzoic acid derivative from plants and fruits, possessing antioxidant, anti-inflammatory, and blood pressure-lowering properties.
Synonyms	Veratrumenoic acid, 3,4-Dimethoxybenzoic acid

Chemical Properties

Molecular Weight	182.17
Formula	C₉H₁₀O₄
Cas No.	93-07-2
Smiles	COC1=C(OC)C=C(C=C1)C(O)=O
Relative Density.	1.2481 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (301.92 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.98 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.4894 mL	27.4469 mL	54.8938 mL	274.4689 mL
5 mM	1.0979 mL	5.4894 mL	10.9788 mL	54.8938 mL
10 mM	0.5489 mL	2.7447 mL	5.4894 mL	27.4469 mL
20 mM	0.2745 mL	1.3723 mL	2.7447 mL	13.7234 mL
50 mM	0.1098 mL	0.5489 mL	1.0979 mL	5.4894 mL
100 mM	0.0549 mL	0.2745 mL	0.5489 mL	2.7447 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc