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PARPi-FL

Name: PARPi-FL
Brand: TargetMol
SKU: T24597
Price: 213 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24597Cas No. 1380359-84-1

Alias PARPiFL, Olaparib-bodipy FL

PARPi-FL (PARPiFL) is a fluorescent PARP1 inhibitor used for imaging glioblastoma and detecting oral cancer.

PARPi-FL

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Purity: 99.73%

Catalog No. T24597Alias PARPiFL, Olaparib-bodipy FLCas No. 1380359-84-1

PARPi-FL (PARPiFL) is a fluorescent PARP1 inhibitor used for imaging glioblastoma and detecting oral cancer.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$213	In Stock	In Stock
5 mg	$538	-	In Stock
10 mg	$793	-	In Stock
25 mg	$1,490	-	In Stock
50 mg	$2,230	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.73%

Appearance:Solid

Color:Red

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	PARPi-FL (PARPiFL) is a fluorescent PARP1 inhibitor used for imaging glioblastoma and detecting oral cancer.
In vitro	The IC50 of PARPi-FL for glioblastoma cell lines U87 and U251 was 27.7 ± 1.3 μM and 8.0 ± 1.2 μM, respectively. [1]
In vivo	PARPi-FL has a half-life of 24.5 minutes t1/2 in mice. PARPi-FL (2.5 mg/kg) 90 minutes after intravenous administration, the concentration of PARPi-FL in tumors was significantly higher than in muscle or brain, indicating that PARPi-FL was able to generate high-contrast images of tumor tissue in the brain. [1] PARPi-FL can be used for fluorescent-guided tumor resection in a mouse model of oral cancer. [2]
Synonyms	PARPiFL, Olaparib-bodipy FL

Chemical Properties

Molecular Weight	640.46
Formula	C₃₄H₃₂BF₃N₆O₃
Cas No.	1380359-84-1
Smiles	O=C1NN=C(CC2=CC=C(C(C(N3CCN(CC3)C(CCC4=CC=C5C=C6C(C)=CC(C)=[N+]6[B-](F)(N54)F)=O)=O)=C2)F)C7=C1C=CC=C7
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (62.46 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5614 mL	7.8069 mL	15.6138 mL	78.0689 mL
5 mM	0.3123 mL	1.5614 mL	3.1228 mL	15.6138 mL
10 mM	0.1561 mL	0.7807 mL	1.5614 mL	7.8069 mL
20 mM	0.0781 mL	0.3903 mL	0.7807 mL	3.9034 mL
50 mM	0.0312 mL	0.1561 mL	0.3123 mL	1.5614 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc