Shopping Cart

Your shopping cart is currently empty

Dihydromethysticin

Name: Dihydromethysticin
Brand: TargetMol
SKU: TQ0191
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. TQ0191Cas No. 19902-91-1

Alias (+)-Dihydromethysticin

Dihydromethysticin ((+)-Dihydromethysticin) is a kavalactone found in Piper methysticum. It has marked activity on the induction of CYP3A23.

Dihydromethysticin

Copy Product Info

😃Good

Purity: 99.85%

Catalog No. TQ0191Alias (+)-DihydromethysticinCas No. 19902-91-1

Dihydromethysticin ((+)-Dihydromethysticin) is a kavalactone found in Piper methysticum. It has marked activity on the induction of CYP3A23.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$64	In Stock	In Stock
5 mg	$152	In Stock	In Stock
10 mg	$228	In Stock	In Stock
25 mg	$347	In Stock	In Stock
50 mg	$496	-	In Stock
100 mg	$693	-	In Stock
1 mL x 10 mM (in DMSO)	$170	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.85%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Dihydromethysticin AI Summary

Dihydromethysticin inhibits TNF-alpha-induced NF-kappaB expression in human A549 cells with an IC50 of 20.0 ug/mL and exhibits hepatotoxicity against mouse Hepa-1c1c7 cells at an IC50 of 313.0 ug/mL after 48 hours using the celltiter blue assay. It also acts as an inhibitor of electric eel acetylcholinesterase (AChE) and horse butyrylcholinesterase (BChE) at a concentration of 2 mg/mL, with 24.84% inhibition of AChE and 3.66% inhibition of BChE according to Ellman's method. Furthermore, Dihydromethysticin demonstrates antifungal activity against various fungi including Hypocrea rufa, Fusarium solani, Colletotrichum gloeosporioides, and Fusarium oxysporum, and exhibits herbicidal activity against Echinochloa crus-galli (barnyard grass) and Lactuca sativa cv. Great Lakes 366 (lettuce), significantly inhibiting root and shoot length as well as germination at various concentrations..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Dihydromethysticin ((+)-Dihydromethysticin) is a kavalactone found in Piper methysticum. It has marked activity on the induction of CYP3A23.
Synonyms	(+)-Dihydromethysticin

Chemical Properties

Molecular Weight	276.28
Formula	C₁₅H₁₆O₅
Cas No.	19902-91-1
Smiles	COC1=CC(=O)O[C@@H](CCc2ccc3OCOc3c2)C1
Relative Density.	1.28 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (108.59 mM), Sonication is recommended.

Ethanol: Soluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.24 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6195 mL	18.0976 mL	36.1952 mL	180.9758 mL
5 mM	0.7239 mL	3.6195 mL	7.2390 mL	36.1952 mL
10 mM	0.3620 mL	1.8098 mL	3.6195 mL	18.0976 mL
20 mM	0.1810 mL	0.9049 mL	1.8098 mL	9.0488 mL
50 mM	0.0724 mL	0.3620 mL	0.7239 mL	3.6195 mL
100 mM	0.0362 mL	0.1810 mL	0.3620 mL	1.8098 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc