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Vinorelbine ditartrate

Name: Vinorelbine ditartrate
Brand: TargetMol
SKU: T6213
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T6213Cas No. 125317-39-7

Alias Vinorelbine Tartrate, Nor-5'-anhydrovinblastine ditartrate, Navelbine tartrate, KW-2307

Vinorelbine ditartrate (KW-2307) is a natural alkaloid and an anti-mitotic agent. Vinorelbine ditartrate has anti-tumor activity, inhibiting cell proliferation and inducing apoptosis.

Vinorelbine ditartrate

🥰Excellent

Purity: 99.93%

Catalog No. T6213Alias Vinorelbine Tartrate, Nor-5'-anhydrovinblastine ditartrate, Navelbine tartrate, KW-2307Cas No. 125317-39-7

Vinorelbine ditartrate (KW-2307) is a natural alkaloid and an anti-mitotic agent. Vinorelbine ditartrate has anti-tumor activity, inhibiting cell proliferation and inducing apoptosis.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	In Stock	In Stock
10 mg	$51	In Stock	In Stock
25 mg	$108	In Stock	In Stock
50 mg	$183	In Stock	In Stock
100 mg	$288	In Stock	In Stock
500 mg	$688	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$61	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.93%

Color:White to Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Vinorelbine ditartrate (KW-2307) is a natural alkaloid and an anti-mitotic agent. Vinorelbine ditartrate has anti-tumor activity, inhibiting cell proliferation and inducing apoptosis.
Targets&IC50	Antimitotic:1.25 nM
In vitro	METHODS: Human lung cancer cells NCI-H460 and A549 were treated with Vinorelbine ditartrate (0.01-10 µM) and DT-13 (10 µM) for 48 h. Cell viability was measured by MTT assay. RESULTS: DT-13 significantly increased the cytotoxicity of Vinorelbine on NCI-H460 and A549 cells. The drug-drug interaction between DT-13 and NVB was calculated by combinatorial index (CI) value, which indicated that the DT-13/Vinorelbine combination therapy showed strong synergistic effects in NSCLC cells. [1] METHODS: APC+ or APC- U2OS cells were treated with Vinorelbine ditartrate (1-50 µg/mL) for 4 h. Apoptosis was detected by Flow cytometry. RESULTS: Vinorelbine-induced cell death was more pronounced in APC-deficient cells, suggesting that the number of aCasp3-containing cells increased after 4 h of treatment with a certain concentration of Vinorelbine. This rapid response to Vinorelbine suggests that death is not associated with mitotic arrest. [2]
In vivo	METHODS: To assay antitumor activity in vivo, vinorelbine ditartrate (1-10 mg/kg, i.v.) and DT-13 (1.25 mg/kg, by gavage) were administered to BALB/c athymic nude mice bearing NCI-H460 xenografts once daily for three weeks. RESULTS: Treatment with Myricetin or cisplatin alone moderately inhibited tumor growth, but the combination treatment inhibited tumor growth more significantly than Myricetin or cisplatin alone. [1]
Synonyms	Vinorelbine Tartrate, Nor-5'-anhydrovinblastine ditartrate, Navelbine tartrate, KW-2307

Chemical Properties

Molecular Weight	1079.11
Formula	C₄₅H₅₄N₄O₈·2C₄H₆O₆
Cas No.	125317-39-7
Smiles	O[C@H]([C@@H](O)C(O)=O)C(O)=O.O[C@H]([C@@H](O)C(O)=O)C(O)=O.CCC1=CC2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C2)(C(=O)OC)c1cc2c(cc1OC)N(C)[C@@H]1[C@]22CCN3CC=C[C@](CC)([C@@H]23)[C@@H](OC(C)=O)[C@]1(O)C(=O)OC
Relative Density.	1.36g/cm3

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 107.9 mg/mL (99.99 mM), Sonication is recommended.

DMSO: 127 mg/mL (117.69 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (4.63 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9267 mL	4.6334 mL	9.2669 mL	46.3345 mL
5 mM	0.1853 mL	0.9267 mL	1.8534 mL	9.2669 mL
10 mM	0.0927 mL	0.4633 mL	0.9267 mL	4.6334 mL
20 mM	0.0463 mL	0.2317 mL	0.4633 mL	2.3167 mL
50 mM	0.0185 mL	0.0927 mL	0.1853 mL	0.9267 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0093 mL	0.0463 mL	0.0927 mL	0.4633 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc