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Risedronic Acid
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Catalog No. T0379Cas No. 105462-24-6
Alias Risedronate
Risedronic Acid (Risedronate), a pyridinyl biphosphonate, can inhibit osteoclast-mediated bone resorption.
Risedronic Acid
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Purity: 99.87%
Catalog No. T0379Alias RisedronateCas No. 105462-24-6
Risedronic Acid (Risedronate), a pyridinyl biphosphonate, can inhibit osteoclast-mediated bone resorption.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $35 | In Stock | In Stock | |
| 50 mg | $48 | In Stock | In Stock | |
| 100 mg | $68 | In Stock | In Stock | |
| 200 mg | $98 | In Stock | In Stock | |
| 500 mg | $179 | In Stock | In Stock | |
| 1 g | $268 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $39 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.87%
Appearance:Solid
Color:White
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Product Introduction
Risedronic Acid AI Summary
Risedronic Acid shows a diverse range of bioactivities, particularly in inhibiting various enzymes and parasites. It inhibits the growth of Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Toxoplasma gondii, Leishmania major, and Plasmodium species, with IC50 values varying from nanomolar to micromolar levels. The compound also demonstrates significant inhibitory activity against farnesyl diphosphate synthase (FPPS) and geranylgeranyl diphosphate synthase (GGPPS) from multiple organisms, with IC50 values as low as 3.9 nM for human FPPS. Risedronic Acid shows considerable antiproliferative effects against various human and parasite cell lines. It has a notable therapeutic index, although toxicity concerns are present, particularly in its cytotoxicity against human KB and HepG2 cell lines. Additionally, it displays anti-inflammatory and bone resorption inhibition properties in rat models. Structurally, Risedronic Acid demonstrates high binding affinity to FPPS, significantly inhibiting enzyme activity and protein prenylation, indicating potential applications in treating diseases related to these pathways. Despite its broad spectrum of activity, it does not show significant inhibitory potential against Aquifex aeolicus IspH or recombinant GGTase 2 enzyme. Furthermore, it has displayed minimal antiviral activity against SARS-CoV-2 and weak binding affinity towards several human receptors..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Risedronic Acid (Risedronate), a pyridinyl biphosphonate, can inhibit osteoclast-mediated bone resorption. |
| Synonyms | Risedronate |
| Molecular Weight | 283.11 |
| Formula | C7H11NO7P2 |
| Cas No. | 105462-24-6 |
| Smiles | O.OC(Cc1cccnc1)(P(O)(O)=O)P(O)(O)=O |
| Relative Density. | 1.870 g/cm3 (Predicted) |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | H2O: Insoluble DMSO: 2.84 mg/mL (10.03 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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