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Macelignan

Name: Macelignan
Brand: TargetMol
SKU: T3866
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3866Cas No. 107534-93-0

Alias Anwuligan, (+)-Anwulignan

Macelignan (Anwuligan) is a lignan isolated from nutmeg with antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus species.

Macelignan

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Purity: 98.01%

Catalog No. T3866Alias Anwuligan, (+)-AnwulignanCas No. 107534-93-0

Macelignan (Anwuligan) is a lignan isolated from nutmeg with antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus species.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$33	In Stock	In Stock
5 mg	$50	In Stock	In Stock
10 mg	$70	In Stock	In Stock
25 mg	$113	In Stock	In Stock
50 mg	$163	In Stock	In Stock
100 mg	$239	-	In Stock
200 mg	$356	-	In Stock
1 mL x 10 mM (in DMSO)	$60	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.01%

Color:White to Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Macelignan AI Summary

Macelignan displays antioxidant activity by inhibiting LDL-oxidation, with an inhibition rate of 64.5% at 20 μM concentration in the TBARS assay and an IC50 value of 7500.0 nM. It also demonstrates the capacity to scavenge DPPH free radicals with IC50 values of 33,170.0 nM and 75,090.0 nM. Besides its antioxidant properties, Macelignan shows neuroprotective effects against amyloid beta (25 to 35)-induced cell death in human SH-SY5Y cells, enhancing cell viability at varying concentrations. Additionally, Macelignan exhibits a proliferative effect on human MCF7 BUS cells, comparable to 17-beta estradiol, despite registering 0.0% activity in these bioassays. It extends its therapeutic potential by displaying inhibitory effects on multiple targets and pathways, including mitochondrial division, Tau fibril formation, human alpha-Glucosidase, chronic active B-cell receptor signaling, and others. This broad spectrum of bioactivities underscores its potential roles in treating cancer, neurodegenerative diseases, malaria, and antiviral conditions. Specifically, Macelignan shows antiviral activity against SARS-CoV-2 by inhibiting induced cytotoxicity in both Caco-2 and VERO-6 cells. The compound also inhibits the SARS-CoV-2 3CL-Pro protease by 17.37% at 20 μM concentration. Furthermore, it demonstrates inhibitory activity on human HDAC6 in enzymatic assays, albeit with low inhibition percentages, suggesting potential but modest efficacy as an HDAC6 inhibitor..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Macelignan (Anwuligan) is a lignan isolated from nutmeg with antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus species.
Synonyms	Anwuligan, (+)-Anwulignan

Chemical Properties

Molecular Weight	328.40
Formula	C₂₀H₂₄O₄
Cas No.	107534-93-0
Smiles	COc1cc(C[C@H](C)[C@H](C)Cc2ccc3OCOc3c2)ccc1O
Relative Density.	1.159g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 135.00 mg/mL (411.08 mM), Sonication is recommended.

Chloroform, Dichloromethane, Ethyl Acetate: Soluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.00 mg/mL (6.09 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0451 mL	15.2253 mL	30.4507 mL	152.2533 mL
5 mM	0.6090 mL	3.0451 mL	6.0901 mL	30.4507 mL
10 mM	0.3045 mL	1.5225 mL	3.0451 mL	15.2253 mL
20 mM	0.1523 mL	0.7613 mL	1.5225 mL	7.6127 mL
50 mM	0.0609 mL	0.3045 mL	0.6090 mL	3.0451 mL
100 mM	0.0305 mL	0.1523 mL	0.3045 mL	1.5225 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc