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Aureusidin

Name: Aureusidin
Brand: TargetMol
SKU: TN5634
Price: 219 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN5634Cas No. 38216-54-5

Alias Auresudidin, Auresidin

Aureusidin (Auresidin) shows antioxidant and lipoxygenase inhibitory activity with anti-inflammatory effects.

Aureusidin

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Purity: 99.18%

Catalog No. TN5634Alias Auresudidin, AuresidinCas No. 38216-54-5

Aureusidin (Auresidin) shows antioxidant and lipoxygenase inhibitory activity with anti-inflammatory effects.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$219	In Stock	In Stock
5 mg	$445	In Stock	In Stock
10 mg	$656	In Stock	In Stock
25 mg	$987	In Stock	In Stock
50 mg	$1,380	In Stock	In Stock
100 mg	$1,880	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$427	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.18%

Appearance:Solid

Color:Orange

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COA

Product Introduction

Aureusidin AI Summary

Aureusidin exhibits a range of bioactivities, including potent antioxidant and enzyme inhibition properties. It demonstrates strong DPPH radical scavenging and high hydrogen peroxide scavenging activities, along with moderate inhibition of soybean 5-lipoxygenase and AAPH-induced lipid peroxidation. Additionally, it acts as a significant inhibitor of HCV genotype 1b NS5B polymerase, showing 85.0% inhibition of double-stranded RNA synthesis at 20 µM and an IC50 value of 5400.0 nM. Furthermore, Aureusidin inhibits CDK5/p25-mediated incorporation of gamma33P into substrates with IC50 values of 4810.0 nM and 3500.0 nM under varying conditions. The compound also targets histone deacetylases (HDACs) such as HDAC1, HDAC2, HDAC4, HDAC6, HDAC7, and HDAC8, with IC50 values ranging from 38,000 nM to 48,500 nM and Ki values from 800.0 nM to 1660.0 nM. Aureusidin exhibits neuroprotective effects against glutamate-induced neurotoxicity in mouse HT-22 cells with an EC50 of 11,900.0 nM. It also significantly inhibits synthetic AcPHF6 peptide aggregation, with inhibition rates up to 93.0% in specific conditions. Moreover, the compound demonstrates cytotoxicity against human MCF7 and HepG2 cells at 15 µM after 72 hours..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Aureusidin (Auresidin) shows antioxidant and lipoxygenase inhibitory activity with anti-inflammatory effects.
Synonyms	Auresudidin, Auresidin

Chemical Properties

Molecular Weight	286.24
Formula	C₁₅H₁₀O₆
Cas No.	38216-54-5
Smiles	Oc1cc2O\C(=C/c3ccc(O)c(O)c3)C(=O)c2c(O)c1
Relative Density.	1.708g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (174.68 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.99 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4936 mL	17.4679 mL	34.9357 mL	174.6786 mL
5 mM	0.6987 mL	3.4936 mL	6.9871 mL	34.9357 mL
10 mM	0.3494 mL	1.7468 mL	3.4936 mL	17.4679 mL
20 mM	0.1747 mL	0.8734 mL	1.7468 mL	8.7339 mL
50 mM	0.0699 mL	0.3494 mL	0.6987 mL	3.4936 mL
100 mM	0.0349 mL	0.1747 mL	0.3494 mL	1.7468 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc