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FAPI-4

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Catalog No. T11264Cas No. 2374782-02-0
Alias FAPI 4, DOTA-fapi-04

FAPI-4 FAPI-4 is a fibroblast activating protein (FAP) inhibitor, a FAPI ligand, which shows strong liver uptake in PET imaging of primary liver cancer hepatocellular carcinoma (HCC) and is commonly used in PET imaging for the study of cancer.

FAPI-4

FAPI-4

😃Good
Purity: 98.79%
Catalog No. T11264Alias FAPI 4, DOTA-fapi-04Cas No. 2374782-02-0
FAPI-4 FAPI-4 is a fibroblast activating protein (FAP) inhibitor, a FAPI ligand, which shows strong liver uptake in PET imaging of primary liver cancer hepatocellular carcinoma (HCC) and is commonly used in PET imaging for the study of cancer.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$4407-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.79%
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COA HNMR HPLC MS

Product Introduction

Bioactivity
Description
FAPI-4 FAPI-4 is a fibroblast activating protein (FAP) inhibitor, a FAPI ligand, which shows strong liver uptake in PET imaging of primary liver cancer hepatocellular carcinoma (HCC) and is commonly used in PET imaging for the study of cancer.
In vivo
In 8-week-old BALB/c nu/nu mice inoculated with HT-1080-FAP cells, FAPI-4 (30 nmol per mouse; intravenous injection; once) revealed high overall tumor uptake[2].
SynonymsFAPI 4, DOTA-fapi-04
Chemical Properties
Molecular Weight872.92
FormulaC40H54F2N10O10
Cas No.2374782-02-0
Smiles[H][C@]1(CC(F)(F)CN1C(=O)CNC(=O)c1ccnc2ccc(OCCCN3CCN(CC3)C(=O)CN3CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC3)cc12)C#N
Relative Density.1.46 g/cm3 (Predicted)
Storage & Solubility Information
Storagekeep away from direct sunlight | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (91.65 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (3.78 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.1456 mL5.7279 mL11.4558 mL57.2790 mL
5 mM0.2291 mL1.1456 mL2.2912 mL11.4558 mL
10 mM0.1146 mL0.5728 mL1.1456 mL5.7279 mL
20 mM0.0573 mL0.2864 mL0.5728 mL2.8640 mL
50 mM0.0229 mL0.1146 mL0.2291 mL1.1456 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

Fibroblast activation proteinFAPI-4FAPI4FAP
Related Tags: buy FAPI-4 | purchase FAPI-4 | FAPI-4 cost | order FAPI-4 | FAPI-4 chemical structure | FAPI-4 in vivo | FAPI-4 formula | FAPI-4 molecular weight
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