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FAPI-4

Name: FAPI-4
Brand: TargetMol
SKU: T11264
Rating: 4.5 (1 reviews)

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Catalog No. T11264Cas No. 2374782-02-0

Alias FAPI 4, DOTA-fapi-04

FAPI-4 FAPI-4 is a fibroblast activating protein (FAP) inhibitor, a FAPI ligand, which shows strong liver uptake in PET imaging of primary liver cancer hepatocellular carcinoma (HCC) and is commonly used in PET imaging for the study of cancer.

FAPI-4

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Purity: 98.79%

Catalog No. T11264Alias FAPI 4, DOTA-fapi-04Cas No. 2374782-02-0

Pack Size	Price	Availability	Quantity
1 mg	$440	7-10 days

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.79%

Resource Download

COA HNMR HPLC MS

Product Introduction

Bioactivity

Description	FAPI-4 FAPI-4 is a fibroblast activating protein (FAP) inhibitor, a FAPI ligand, which shows strong liver uptake in PET imaging of primary liver cancer hepatocellular carcinoma (HCC) and is commonly used in PET imaging for the study of cancer.
In vivo	In 8-week-old BALB/c nu/nu mice inoculated with HT-1080-FAP cells, FAPI-4 (30 nmol per mouse; intravenous injection; once) revealed high overall tumor uptake[2].
Synonyms	FAPI 4, DOTA-fapi-04

Chemical Properties

Molecular Weight	872.92
Formula	C₄₀H₅₄F₂N₁₀O₁₀
Cas No.	2374782-02-0
Smiles	[H][C@]1(CC(F)(F)CN1C(=O)CNC(=O)c1ccnc2ccc(OCCCN3CCN(CC3)C(=O)CN3CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC3)cc12)C#N
Relative Density.	1.46 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (91.65 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1456 mL	5.7279 mL	11.4558 mL	57.2790 mL
5 mM	0.2291 mL	1.1456 mL	2.2912 mL	11.4558 mL
10 mM	0.1146 mL	0.5728 mL	1.1456 mL	5.7279 mL
20 mM	0.0573 mL	0.2864 mL	0.5728 mL	2.8640 mL
50 mM	0.0229 mL	0.1146 mL	0.2291 mL	1.1456 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc