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Vulpinic Acid

Name: Vulpinic Acid
Brand: TargetMol
SKU: T3982
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3982Cas No. 521-52-8

Alias Vulpic acid, Pulvinic acid methyl ester

Vulpinic Acid (Pulvinic acid methyl ester) is a lichen metabolite with anti-inflammatory, antibacteria, properties, plant growth inhibitor.

Vulpinic Acid

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Purity: 99.69%

Catalog No. T3982Alias Vulpic acid, Pulvinic acid methyl esterCas No. 521-52-8

Vulpinic Acid (Pulvinic acid methyl ester) is a lichen metabolite with anti-inflammatory, antibacteria, properties, plant growth inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	In Stock	In Stock
25 mg	$46	In Stock	In Stock
50 mg	$68	In Stock	In Stock
100 mg	$100	In Stock	In Stock
200 mg	$146	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.69%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Vulpinic Acid AI Summary

Vulpinic Acid exhibits a broad spectrum of bioactivity. It demonstrates antimicrobial activity against Staphylococcus aureus with an IC50 value of 20.0 µg/mL and has an inhibitory effect on COX1 with an IC50 value of 218.0 µg/mL. Additionally, it inhibits 7,12-dimethylbenz[a]anthracene-induced preneoplastic lesions in BALB/c mouse mammary gland culture, with an IC50 greater than 10.0 µg/mL. In various biochemical assays, Vulpinic Acid inhibits Tau fibril formation and Thioflavin T binding with an IC50 of 223.9 nM, Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia with an IC50 of 17,740.7 nM, and Human Apurinic/apyrimidinic Endonuclease 1 (APE1) with an IC50 of 5.0 nM. It also shows limited inhibitory activity on electric eel AChE and horse BChE with inhibition rates of 4.9% and 0.35%, respectively, at 2 mg/mL. The compound affects insect development, causing imago developmental aberrations, changes in pupal weight, prolonged larval periods, and growth retardation in Spodoptera littoralis. In zebrafish larva, Vulpinic Acid exhibits hepatotoxicity at ≥ 40.0% activity and general toxicity with an MTD of 15.5 µM. It has cytotoxicity against human Huh7.5 cells with an IC50 greater than 100,000.0 nM. The antibacterial properties are shown against Staphylococcus aureus and Escherichia coli, along with inhibition of FabI enzymes in several pathogens such as Escherichia coli, Staphylococcus aureus, Mycobacterium tuberculosis, and Plasmodium falciparum. Moreover, it significantly inhibits sodium fluorescein uptake in OATP1B1-transfected CHO cells (57.14%) and OATP1B3-transfected CHO cells (83.34%) at 10 µM. It exhibits antiviral activity against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in VERO-6 cells with IC50 values > 20,000.0 nM and > 19,952.62 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Vulpinic Acid (Pulvinic acid methyl ester) is a lichen metabolite with anti-inflammatory, antibacteria, properties, plant growth inhibitor.
Synonyms	Vulpic acid, Pulvinic acid methyl ester

Chemical Properties

Molecular Weight	322.31
Formula	C₁₉H₁₄O₅
Cas No.	521-52-8
Smiles	COC(=O)C(=C1\OC(=O)C(=C1O)c1ccccc1)\c1ccccc1
Relative Density.	1.375g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (186.16 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.1 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1026 mL	15.5130 mL	31.0260 mL	155.1302 mL
5 mM	0.6205 mL	3.1026 mL	6.2052 mL	31.0260 mL
10 mM	0.3103 mL	1.5513 mL	3.1026 mL	15.5130 mL
20 mM	0.1551 mL	0.7757 mL	1.5513 mL	7.7565 mL
50 mM	0.0621 mL	0.3103 mL	0.6205 mL	3.1026 mL
100 mM	0.0310 mL	0.1551 mL	0.3103 mL	1.5513 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc