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FB23
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Catalog No. T8874Cas No. 2243736-35-6
FB23 directly binds to FTO and selectively inhibits FTO's m6A demethylase activity. (FTO, an mRNA N6-methyladenosine (m6A) demethylase, was reported to promote leukemogenesis.)
FB23
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Purity: 99.19%
Catalog No. T8874Cas No. 2243736-35-6
FB23 directly binds to FTO and selectively inhibits FTO's m6A demethylase activity. (FTO, an mRNA N6-methyladenosine (m6A) demethylase, was reported to promote leukemogenesis.)
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $45 | In Stock | In Stock | |
| 2 mg | $64 | In Stock | In Stock | |
| 5 mg | $101 | In Stock | In Stock | |
| 10 mg | $179 | In Stock | In Stock | |
| 25 mg | $369 | In Stock | In Stock | |
| 50 mg | $571 | In Stock | In Stock | |
| 100 mg | $819 | In Stock | In Stock | |
| 500 mg | $1,690 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $118 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.19%
Color:White
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Product Introduction
FB23 AI Summary
FB23 exhibits significant bioactivity as an inhibitor of the FTO enzyme, with an IC50 value of 60.0 nM, making it a potent demethylation inhibitor. It demonstrates a high inhibition rate (98.0%) against N-terminal His-tagged human FTO expressed in Escherichia coli at 20 µM. Additionally, FB23 has shown cytotoxic effects, evidenced by 70.0% and 75.0% growth inhibition of human NB4 and MM6 cells, respectively, as measured by MTS assay. Its potency against these cells shows IC50 values of 44,800.0 nM for NB4 cells and 23,600.0 nM for MM6 cells. Furthermore, the compound also demonstrated an inhibitory effect in a PAGE-based assay for the FTO enzyme with an IC50 value of 400.0 nM. Overall, its potent inhibition of FTO-mediated m6A demethylation activity highlights its potential as a valuable compound in related biomedical research..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | FB23 directly binds to FTO and selectively inhibits FTO's m6A demethylase activity. (FTO, an mRNA N6-methyladenosine (m6A) demethylase, was reported to promote leukemogenesis.) |
| Targets&IC50 | FTO:60 nM (IC50) |
| Molecular Weight | 377.22 |
| Formula | C18H14Cl2N2O3 |
| Cas No. | 2243736-35-6 |
| Smiles | Cc1noc(C)c1-c1cc(Cl)c(Nc2ccccc2C(O)=O)c(Cl)c1 |
| Relative Density. | 1.419 g/cm3 (Predicted) |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 25 mg/mL (66.27 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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