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Anti-CD11b Antibody (3A561)
😃Good
Catalog No. TMAB-03826
Anti-CD11b Antibody (3A561) is a Mouse antibody targeting CD11b. Anti-CD11b Antibody (3A561) can be used in FCM.
Anti-CD11b Antibody (3A561)
Anti-CD11b Antibody (3A561)
😃Good
Catalog No. TMAB-03826
Anti-CD11b Antibody (3A561) is a Mouse antibody targeting CD11b. Anti-CD11b Antibody (3A561) can be used in FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 100 μg | $352 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-CD11b Antibody (3A561) is a Mouse antibody targeting CD11b. Anti-CD11b Antibody (3A561) can be used in FCM. |
| Ig Type | Mouse IgG1, k |
| Clone | 3A561 |
| Reactivity | Human |
| Application | |
| Recommended Dose | FCM: 1μg/Test |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Membrane. |
| Tissue Specificity | Predominantly expressed in monocytes and granulocytes. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein G purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4). |
| Concentration | 1mg/ml |
| Research Background | This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] |
| Immunogen | Recombinant Protein: human CD11b |
| Antigen Species | Human |
| Gene Name | ITGAM |
| Gene ID | |
| Protein Name | Integrin alpha-M |
| Uniprot ID | |
| Function | Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. |
| Molecular Weight | Theoretical: 125 kDa. Actual: 165-170 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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