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Lomefloxacin
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Catalog No. T1444Cas No. 98079-51-7
Alias SC47111A
Lomefloxacin (SC47111A) is a synthetic broad-spectrum fluoroquinolone with antibacterial activity.
Lomefloxacin
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Purity: 99.88%
Catalog No. T1444Alias SC47111ACas No. 98079-51-7
Lomefloxacin (SC47111A) is a synthetic broad-spectrum fluoroquinolone with antibacterial activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 100 mg | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.88%
Appearance:Solid
Color:White
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Product Introduction
Lomefloxacin AI Summary
Lomefloxacin exhibits broad-spectrum antibacterial activity against both gram-negative and gram-positive bacteria, including Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, and Pseudomonas aeruginosa, with MIC values ranging from 0.02 to 0.1 µg/mL for some strains. It demonstrates especially strong efficacy against gram-negative organisms such as Escherichia coli and Klebsiella pneumoniae, with MIC values as low as 0.1 µg/mL. The compound also inhibits Escherichia coli DNA-gyrase and shows significant antibacterial activity against multidrug-resistant strains. Additionally, Lomefloxacin displays antimicrobial properties against various strains of Mycobacterium, including Mycobacterium tuberculosis and Mycobacterium smegmatis, with MIC values up to 10.0 µg/mL.
In vitro assays have revealed moderate permeability characteristics; the compound exhibited a permeability value of 1.1 x 10^-6 cm/s in the PAMPA-BBB assay, suggesting potential ability to cross the blood-brain barrier. Pharmacokinetic studies noted high oral bioavailability of approximately 98.0% and a high volume of distribution (Vdss = 2.3 L.kg^-1).
Lomefloxacin also demonstrated antitrypanosomal activity against Trypanosoma brucei brucei, with an IC50 value of 197,000.0 nM. Moreover, it showed inhibition of human enzymes such as Histone Lysine Methyltransferase G9a, Thioredoxin Reductase 1 (TrxR1), and Flap endonuclease 1 (FEN1) at sub-micromolar concentrations.
However, compound 16278 exhibited phototoxic effects in UV-irradiated Swiss albino mice, with ear thickness measurements increasing after a dose of 140 mg/kg, peaking at 72 hours post-irradiation. It also demonstrated liver enzyme alterations indicative of moderate hepatotoxicity in clinical-chemistry studies. Furthermore, the compound displayed antiviral activity against SARS-CoV-2, though with moderate efficacy as indicated by its IC50 value.
Overall, Lomefloxacin holds promise as a potential antimicrobial and antiparasitic agent, with noteworthy permeability and bioavailability attributes, but its phototoxic and hepatotoxic effects warrant careful consideration in further development..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Lomefloxacin (SC47111A) is a synthetic broad-spectrum fluoroquinolone with antibacterial activity. |
| Synonyms | SC47111A |
| Molecular Weight | 351.35 |
| Formula | C17H19F2N3O3 |
| Cas No. | 98079-51-7 |
| Smiles | C(C)N1C=2C(C(=O)C(C(O)=O)=C1)=CC(F)=C(C2F)N3CC(C)NCC3 |
| Relative Density. | 1.342 g/cm3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | DMSO: 1.07 mg/mL (3.05 mM), Sonication is recommended.  | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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