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p-Coumaric acid

Name: p-Coumaric acid
Brand: TargetMol
SKU: T2863
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2863Cas No. 501-98-4

Alias Trans-p-Coumaric acid, trans-4-Hydroxycinnamic acid, P-Hydroxycinnamic acid, para-Coumaric Acid, 4-Hydroxycinnamic acid, 4-Coumaric acid

p-Coumaric acid (para-Coumaric Acid) is the abundant isomer of cinnamic acid, with antitumor and anti-mutagenic activities.

p-Coumaric acid

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Purity: 99.64%

Catalog No. T2863Alias Trans-p-Coumaric acid, trans-4-Hydroxycinnamic acid, P-Hydroxycinnamic acid, para-Coumaric Acid, 4-Hydroxycinnamic acid, 4-Coumaric acidCas No. 501-98-4

p-Coumaric acid (para-Coumaric Acid) is the abundant isomer of cinnamic acid, with antitumor and anti-mutagenic activities.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$31	In Stock	In Stock
500 mg	$48	In Stock	In Stock
1 g	$68	In Stock	In Stock
5 g	$96	-	In Stock
10 g	$125	-	In Stock
25 g	$198	-	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.64%

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

p-Coumaric acid AI Summary

p-Coumaric acid demonstrates a wide spectrum of bioactivities across various biological pathways and targets. It notably inhibits the epidermal growth factor receptor kinase, alpha-glucosidase, and tyrosinase, showing moderate to potent inhibitory concentrations (IC50 values ranging from 3,000 nM to several M). It also exhibits antioxidant properties, such as scavenging DPPH radicals, with documented IC50 values indicative of moderate effectiveness. In terms of antimicrobial effects, p-Coumaric acid displays significant activity against various bacterial strains, including Bacillus subtilis, Escherichia coli, Methicillin-resistant Staphylococcus aureus (MICs ranging from 2.0 to 32.0 µg/mL), and moderate antifungal properties against species like Verticillium dahliae. It also shows inhibitory effects on virus-related cytotoxicity, particularly against SARS-CoV-2, by inhibiting 3CL-Pro protease. p-Coumaric acid exhibits several physiological effects in animals, including reductions in fat deposits and impacts on plasma levels of various lipids and glucose. Furthermore, it demonstrates cytotoxicity against multiple cancer cell lines (IC50 values often > 10,000 nM) and neuroprotective properties, such as against glutamate-induced cell death in mouse HT-22 cells (EC50 = 6,400 nM). Additionally, this compound reveals potential in anti-inflammatory applications by inhibiting LPS-induced NO production in mouse RAW264.7 cells and modulating other inflammatory mediators. It has been shown to inhibit aldose reductase with an IC50 of 140 nM, highlighting potential in diabetic complications management. Finally, p-Coumaric acid demonstrates promising bioactivity as an estrogen receptor agonist and ligand-gated ion channel inhibitor. Overall, p-Coumaric acid displays versatile bioactivity profiles with implications for therapeutic applications in cancer, metabolic disorders, antimicrobial treatments, neuroprotection, and anti-inflammatory therapies..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	p-Coumaric acid (para-Coumaric Acid) is the abundant isomer of cinnamic acid, with antitumor and anti-mutagenic activities.
Synonyms	Trans-p-Coumaric acid, trans-4-Hydroxycinnamic acid, P-Hydroxycinnamic acid, para-Coumaric Acid, 4-Hydroxycinnamic acid, 4-Coumaric acid

Chemical Properties

Molecular Weight	164.16
Formula	C₉H₈O₃
Cas No.	501-98-4
Smiles	OC(=O)\C=C\C1=CC=C(O)C=C1
Relative Density.	1.1403 g/cm3 (Estimated)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55.5 mg/mL (338.08 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (24.37 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.0916 mL	30.4581 mL	60.9162 mL	304.5809 mL
5 mM	1.2183 mL	6.0916 mL	12.1832 mL	60.9162 mL
10 mM	0.6092 mL	3.0458 mL	6.0916 mL	30.4581 mL
20 mM	0.3046 mL	1.5229 mL	3.0458 mL	15.2290 mL
50 mM	0.1218 mL	0.6092 mL	1.2183 mL	6.0916 mL
100 mM	0.0609 mL	0.3046 mL	0.6092 mL	3.0458 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc