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Sertindole

Name: Sertindole
Brand: TargetMol
SKU: T5858
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5858Cas No. 106516-24-9

Alias Lu 23-174

Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C, with Kds of 2.7, 20, 0.14, and 6 nM, respectively.

Sertindole

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Purity: 99.92%

Catalog No. T5858Alias Lu 23-174Cas No. 106516-24-9

Pack Size	Price	Availability
5 mg	$45	In Stock
10 mg	$59	In Stock
25 mg	$146	In Stock
50 mg	$290	In Stock
100 mg	$395	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock

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Purity:99.92%

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Product Introduction

Bioactivity

Description	Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C, with Kds of 2.7, 20, 0.14, and 6 nM, respectively.
In vivo	In vivo, sertindole (10 mg/kg) increases extracellular dopamine, acetylcholine (ACh), and glutamate levels in the medial prefrontal cortex in conscious rats[1].Sertindole (2.5 mg/kg) reverses ketamine-induced impairments in the extradimensional shift stage of the attentional set-shifting task (ASST) in rats[2].It reverses phencyclidine (PCP)-induced selective reversal learning deficits in rats and subchronic PCP-induced deficits in the novel object recognition task in mice[3].
Animal Research	Rats were treated acutely with vehicle or drugs, and extracellular levels of neurotransmitters were assessed by microdialysis in freely moving animals[1].
Synonyms	Lu 23-174

Chemical Properties

Molecular Weight	440.94
Formula	C₂₄H₂₆ClFN₄O
Cas No.	106516-24-9
Smiles	Fc1ccc(cc1)-n1cc(C2CCN(CCN3CCNC3=O)CC2)c2cc(Cl)ccc12
Relative Density.	1.36 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (113.39 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2679 mL	11.3394 mL	22.6788 mL	113.3941 mL
5 mM	0.4536 mL	2.2679 mL	4.5358 mL	22.6788 mL
10 mM	0.2268 mL	1.1339 mL	2.2679 mL	11.3394 mL
20 mM	0.1134 mL	0.5670 mL	1.1339 mL	5.6697 mL
50 mM	0.0454 mL	0.2268 mL	0.4536 mL	2.2679 mL
100 mM	0.0227 mL	0.1134 mL	0.2268 mL	1.1339 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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