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Anti-IKBKB Antibody (2I679)
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Catalog No. TMAH-00603
Alias IKBKB
Anti-IKBKB Antibody (2I679) is an antibody targeting IKBKB. Anti-IKBKB Antibody (2I679) can be used in ELISA, WB.
Anti-IKBKB Antibody (2I679)
Anti-IKBKB Antibody (2I679)
😃Good
Catalog No. TMAH-00603Alias IKBKB
Anti-IKBKB Antibody (2I679) is an antibody targeting IKBKB. Anti-IKBKB Antibody (2I679) can be used in ELISA, WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $209 | 7-10 days | |
| 100 μL | $347 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Rabbit Monoclonal Application: ELISA, WB Reactivity: Human |
| Alias | IKBKB |
| Ig Type | Rabbit IgG |
| Clone | 2I679 |
| Reactivity | Human |
| Verified Activity | Western Blot -Positive WB detected in: Hela whole cell lysate, Jurkat whole cell lysate, K562 whole cell lysate -All lanes: IKBKB antibody at 1:2000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 87, 86, 30, 80 kDa -Observed band size: 87 kDa |
| Application | ELISA, WB |
| Recommended Dose | WB:1:500-1:5000. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cytoplasm. Nucleus. Membrane raft. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation. Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death. Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human IKK beta |
| Antigen Species | Human |
| Gene ID | 3551 |
| Uniprot ID | |
| Biology Area | Epigenetics and Nuclear Signaling, Cardiovascular, Immunology, Signal transduction |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
Sci Citations
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Serine/threonine protein kinase IKBKBNuclear factor NF-kappa-B inhibitor kinase β (NFKBIKB)Nuclear factor NF-kappa-B inhibitor kinase beta (NFKBIKB)Nuclear factor NF-kappa-B inhibitor kinase b (NFKBIKB)NFKBIKBInhibitor of nuclear factor kappa-B kinase subunit βInhibitor of nuclear factor kappa-B kinase subunit betaInhibitor of nuclear factor kappa-B kinase subunit bIKK-βIKKβIKK-betaIKK-BIKKBIKK-2IKK2I-kappa-B-kinase βI-kappa-B-kinase betaI-kappa-B-kinase bI-kappa-B kinase 2 (IKK-2;IKK2)
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