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store at -80°C
Farletuzumab (MORAb-003) is a potent inhibitor of folate receptor-α (FRα). Farletuzumab is a humanized monoclonal antibody with a high affinity for FRα. Farletuzumab inhibits the growth of cells that overexpress FRα. Farletuzumab can be used to study cancer.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 372.00 | |
5 mg | In stock | $ 933.00 | |
10 mg | In stock | $ 1,490.00 | |
25 mg | In stock | $ 2,190.00 | |
50 mg | In stock | $ 2,970.00 | |
100 mg | In stock | $ 3,930.00 |
Description | Farletuzumab (MORAb-003) is a potent inhibitor of folate receptor-α (FRα). Farletuzumab is a humanized monoclonal antibody with a high affinity for FRα. Farletuzumab inhibits the growth of cells that overexpress FRα. Farletuzumab can be used to study cancer. |
In vitro |
In CHO-FR cells, Farletuzumab (MORAb-003; 0-10 µg/mL) inhibits FRα-dependent cell growth and increases folate EC50 in a dose-dependent manner[1]. In IGROV-1 cells (0.1-100 µg/mL; 1 h), Farletuzumab mediates tumor cytotoxicity in vitro through complement-dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC)[1]. In CHO-FR cells (0-10 µg/mL), Farletuzumab inhibits the phosphorylation of proteins by Lyn kinase, a member of the src family of kinases, thereby blocking an FRα-mediated signaling pathway[1]. |
Synonyms | MORAb-003 |
Molecular Weight | N/A |
CAS No. | 896723-44-7 |
store at low temperature
store at -80°C
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Farletuzumab 896723-44-7 Cell Cycle/Checkpoint Antifolate MORAb-003 inhibitor inhibit