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Isodeoxycholic Acid

Catalog No. T36585 CAS 566-17-6

Synonyms: isoDCA

Isodeoxycholic Acid is a bile acid that is formed via epimerization of deoxycholic acid by intestinal bacteria. It has a greater critical micelle concentration than DCA, indicating reduced detergent activity, and is less active than DCA in inhibiting growth in a panel of seven gut commensal bacteria species. Isodeoxycholic Acid(0.1%) inhibits spore germination induced by taurocholic acid in several C. difficile strains, as well as decreases the cytotoxicity of C. difficile culture supernatants to Vero cells. Plasma levels of isodeoxycholic acid are decreased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet.

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Isodeoxycholic Acid, CAS 566-17-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 55.00
5 mg	In stock	$ 197.00
10 mg	In stock	$ 322.00
25 mg	In stock	$ 622.00
50 mg	In stock	$ 879.00
100 mg	In stock	$ 1,180.00

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Purity: 98.12%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

Isodeoxycholic acid (0.1%) inhibits spore germination induced by taurocholic acid in several C. difficile strains, as well as decrease the cytotoxicity of C. difficile culture supernatants to Vero cells.[3]

Synonyms	isoDCA
Molecular Weight	392.57
Formula	C24H40O4
CAS No.	566-17-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMF: 27.0 mg/mL (68.8 mM)

Ethanol: 18.0 mg/mL (45.8 mM)

DMSO: 18.0 mg/mL (45.8 mM)

DMF:PBS (pH 7.2) (1:1): 0.5 mg/mL

References and Literature

1. Takei H, et al. Characterization of long-chain fatty acid-linked bile acids: a major conjugation form of 3β-hydroxy bile acids in feces. J Lipid Res. 2022;63(10):100275. 2. Devlin AS, et al. A biosynthetic pathway for a prominent class of microbiota-derived bile acids. Nat Chem Biol. 2015;11(9):685-690. 3. Thanissery R, et al. Inhibition of spore germination, growth, and toxin activity of clinically relevant C. difficile strains by gut microbiota derived secondary bile acids. Anaerobe. 2017;45:86-100. 4. Lin H, et al. Alterations of Bile Acids and Gut Microbiota in Obesity Induced by High Fat Diet in Rat Model. J Agric Food Chem. 2019;67(13):3624-3632.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compounds Library Max Gut Microbial Metabolite Library Natural Product Library for HTS Bioactive Compound Library Anti-infective Natural Product Library Human Metabolite Library

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Keywords

Isodeoxycholic Acid 566-17-6 Membrane transporter/Ion channel Microbiology/Virology Chloride channel Antibacterial isoDCA inhibitor inhibit

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