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Validamycin A

Name: Validamycin A
Brand: TargetMol
SKU: T38268
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38268Cas No. 37248-47-8

Validamycin A is an antibiotic and fungicide that inhibits the alginate enzyme trehalase and thus protects crops from the fungus Rhizoctonia solani, as well as being a reversible inhibitor of tyrosinase.

Validamycin A

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Purity: 98.84%

Catalog No. T38268Cas No. 37248-47-8

Pack Size	Price	Availability
50 mg	$30	In Stock
100 mg	$42	In Stock
500 mg	$98	In Stock

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Batch Information

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Purity:98.84%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Validamycin A is an antibiotic and fungicide that inhibits the alginate enzyme trehalase and thus protects crops from the fungus Rhizoctonia solani, as well as being a reversible inhibitor of tyrosinase.
In vitro	Validamycin A (0.1–5 mg/mL, 2-day treatment) significantly inhibited the growth of Xanthomonas oryzae pv. oryzae (Xoo), with a minimum inhibitory concentration of 1 mg/mL. Scanning electron microscopy revealed bubbling and morphological damage on bacterial surfaces, indicating direct antibacterial effects[1].
In vivo	In rice plant models, foliar spraying of Validamycin A (200 μg/mL, once every 3 days for a total of 3 treatments) significantly reduced disease severity caused by Xoo infection, with average lesion length decreased by approximately 60%. The treatment showed effective in vivo disease control without phytotoxicity[1].

Chemical Properties

Molecular Weight	497.49
Formula	C₂₀H₃₅NO₁₃
Cas No.	37248-47-8
Smiles	O([C@@H]1[C@@H](CO)C[C@H](N[C@H]2C=C(CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O)[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O
Relative Density.	1.69 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

PBS (pH 7.2): 10 mg/mL (20.1 mM), Sonication is recommended.

H2O: 120 mg/mL (241.21 mM), Sonication is recommended.

DMSO: 1 mg/mL (2.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO/PBS (pH 7.2)/H2O

	1mg	5mg	10mg	50mg
1 mM	2.0101 mL	10.0505 mL	20.1009 mL	100.5045 mL

PBS (pH 7.2)/H2O

	1mg	5mg	10mg	50mg
5 mM	0.4020 mL	2.0101 mL	4.0202 mL	20.1009 mL
10 mM	0.2010 mL	1.0050 mL	2.0101 mL	10.0505 mL
20 mM	0.1005 mL	0.5025 mL	1.0050 mL	5.0252 mL

H2O

	1mg	5mg	10mg	50mg
50 mM	0.0402 mL	0.2010 mL	0.4020 mL	2.0101 mL
100 mM	0.0201 mL	0.1005 mL	0.2010 mL	1.0050 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc