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Validamycin A

Name: Validamycin A
Brand: TargetMol
SKU: T38268
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38268Cas No. 37248-47-8

Validamycin A is an antibiotic and fungicide that inhibits the alginate enzyme trehalase and thus protects crops from the fungus Rhizoctonia solani, as well as being a reversible inhibitor of tyrosinase.

Validamycin A

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Purity: 98.84%

Catalog No. T38268Cas No. 37248-47-8

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	-	In Stock
100 mg	$40	-	In Stock
500 mg	$92	-	In Stock
1 g	$133	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.84%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Validamycin A is an antibiotic and fungicide that inhibits the alginate enzyme trehalase and thus protects crops from the fungus Rhizoctonia solani, as well as being a reversible inhibitor of tyrosinase.
In vitro	Validamycin A (0.1–5 mg/mL, 2-day treatment) significantly inhibited the growth of Xanthomonas oryzae pv. oryzae (Xoo), with a minimum inhibitory concentration of 1 mg/mL. Scanning electron microscopy revealed bubbling and morphological damage on bacterial surfaces, indicating direct antibacterial effects[1].
In vivo	In rice plant models, foliar spraying of Validamycin A (200 μg/mL, once every 3 days for a total of 3 treatments) significantly reduced disease severity caused by Xoo infection, with average lesion length decreased by approximately 60%. The treatment showed effective in vivo disease control without phytotoxicity[1].

Chemical Properties

Molecular Weight	497.49
Formula	C₂₀H₃₅NO₁₃
Cas No.	37248-47-8
Smiles	O([C@@H]1[C@@H](CO)C[C@H](N[C@H]2C=C(CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O)[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O
Relative Density.	1.69 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

PBS (pH 7.2): 10 mg/mL (20.1 mM), Sonication is recommended.

H2O: 120 mg/mL (241.21 mM), Sonication is recommended.

DMSO: 1 mg/mL (2.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO/PBS (pH 7.2)/H2O

	1mg	5mg	10mg	50mg
1 mM	2.0101 mL	10.0505 mL	20.1009 mL	100.5045 mL

PBS (pH 7.2)/H2O

	1mg	5mg	10mg	50mg
5 mM	0.4020 mL	2.0101 mL	4.0202 mL	20.1009 mL
10 mM	0.2010 mL	1.0050 mL	2.0101 mL	10.0505 mL
20 mM	0.1005 mL	0.5025 mL	1.0050 mL	5.0252 mL

H2O

	1mg	5mg	10mg	50mg
50 mM	0.0402 mL	0.2010 mL	0.4020 mL	2.0101 mL
100 mM	0.0201 mL	0.1005 mL	0.2010 mL	1.0050 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc