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Anti-BCAM Antibody (5W424)
😃Good
Catalog No. TMAY-03778
Alias basal cell adhesion molecule (Lutheran blood group)
Anti-BCAM Antibody (5W424) is a Rabbit antibody targeting BCAM. Anti-BCAM Antibody (5W424) can be used in IHC-P.
Anti-BCAM Antibody (5W424)
Anti-BCAM Antibody (5W424)
😃Good
Catalog No. TMAY-03778Alias basal cell adhesion molecule (Lutheran blood group)
Anti-BCAM Antibody (5W424) is a Rabbit antibody targeting BCAM. Anti-BCAM Antibody (5W424) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $268 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-BCAM Antibody (5W424) is a Rabbit antibody targeting BCAM. Anti-BCAM Antibody (5W424) can be used in IHC-P. |
| Alias | basal cell adhesion molecule (Lutheran blood group) |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 5W424 |
| Reactivity | Rat |
| Verified Activity | 1. Immunochemical staining of rat BCAM in rat skin with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of rat BCAM in rat liver with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). 3. Immunochemical staining of rat BCAM in rat kidney with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:100-1:500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Rat BCAM / CD239 (rR BCAM / CD239; TMPY-02999; Q9ESS6; Met1-Ala543). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | The Lutheran (Lu) blood group and basal cell adhesion molecule (BCAM) antigens are both carried by 2 glycoprotein isoforms of the immunoglobulin superfamily representing receptors for the laminin alpha(5) chain. It is a transmembrane receptor with five immunoglobulin-like domains in its extracellular region, and is therefore classified as a member of the immunoglobulin (Ig) gene family. In addition to red blood cells, Lu/BCAM proteins are expressed in endothelial cells of vascular capillaries and in epithelial cells of several tissues. BCAM/LU has a wide tissue distribution with a predominant expression in the basal layer of the epithelium and the endothelium of blood vessel walls. As designated as CD239 recently, BCAM and LU share a significant sequence similarity with the CD146 (MUC18) and CD166, and themselves are adhesion molecules that bind laminin with high affinity. Laminins are found in all basement membranes and are involved in cell differentiation, adhesion, migration, and proliferation. BCAM is upregulated following malignant transformation of some cell types in vivo and in vitro, thus being a candidate molecule involved in tumor progression. In addition, BCAM interacts with integrin in sickle red cells, and thus may potentially play a role in vaso-occlusive episodes. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Rat BCAM / CD239 protein (TMPY-02999) |
| Antigen Species | Rat |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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