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Synonyms: Inhibinβ A chain, Inhibin β A chain, Inhibin beta A chain, Inhibin b A chain, INHBA, Erythroid differentiation protein (EDF), EDF, Activinβ-A chain, ActivinβA chain, Activinβ A chain, Activin β-A chain, Activin βA chain, Activin β A chain, Activin beta-A chain, Activin betaA chain, Activin beta A chain, Activin b-A chain, Activin bA chain, Activin b A chain, Activin A


| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $74 | 7-10 days | 7-10 days | |
| 10 µg | $113 | 7-10 days | 7-10 days | |
| 20 µg | $175 | 7-10 days | 7-10 days | |
| 50 µg | $316 | 7-10 days | 7-10 days | |
| 100 µg | $490 | 7-10 days | 7-10 days | |
| 200 µg | $793 | 7-10 days | 7-10 days | |
| 500 µg | $1,470 | 7-10 days | 7-10 days |
| Bioactivity | Immobilized Human Latent Activin A, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Human/Cynomolgus Activin RIIB, hFc Tag with the EC50 of 16.6 ng/ml determined by ELISA (QC Test). |
| Description | Latent Activin A Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is P08476. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | N-His |
| Accession Number | P08476 |
| Construction | Ser21-Ser426 |
| Protein Purity | > 95% as determined by Bis-Tris PAGE |
| Endotoxin | < 1 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Synonyms | Inhibinβ A chain, Inhibin β A chain, Inhibin beta A chain, Inhibin b A chain, INHBA, Erythroid differentiation protein (EDF), EDF, Activinβ-A chain, ActivinβA chain, Activinβ A chain, Activin β-A chain, Activin βA chain, Activin β A chain, Activin beta-A chain, Activin betaA chain, Activin beta A chain, Activin b-A chain, Activin bA chain, Activin b A chain, Activin A |
| Research Background | Activin-A, a member of the TGF-β superfamily, Extensive research over the past decades illuminated fundamental roles for activin-A in essential biologic processes, including embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation and tissue fibrosis. Activin-A signals through two type I and two type II receptors which, upon ligand binding, activate their kinase activity, phosphorylate the SMAD2 and 3 intracellular signaling mediators that form a complex with SMAD4, translocate to the nucleus and activate or silence gene expression. |
| Molecular Weight | 13.0 kDa (mature form) and 32.0 kDa (pro form) (Predicted); 15 kDa (mature form) and 40-50 kDa (pro form) (Reducing condition, due to glycosylation and interchain disulfide bond) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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