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GSK2795039

🥰Excellent
Catalog No. T15433Cas No. 1415925-18-6

GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) (pIC50: 6 in different cell-free assays).

GSK2795039

GSK2795039

🥰Excellent
Purity: 97.72%
Catalog No. T15433Cas No. 1415925-18-6
GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) (pIC50: 6 in different cell-free assays).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$67In StockIn Stock
2 mg$98In StockIn Stock
5 mg$163In StockIn Stock
10 mg$255In StockIn Stock
25 mg$452In StockIn Stock
50 mg$657In StockIn Stock
100 mg$935In StockIn Stock
1 mL x 10 mM (in DMSO)$178In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:97.72%
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Product Introduction

Bioactivity
Description
GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) (pIC50: 6 in different cell-free assays).
In vitro
GSK2795039 (25 μM; 24 hours) mitigates FeSO4 and LPS-induced apoptosis and reduces caspase-3-positive PC12 cells[2].
In vivo
GSK2795039 (intraperitoneal injection; 100 mg/kg; 1 hour prior) reduces activity in a murine acute pancreatitis model and decreases serum amylase levels induced by systemic cerulein injection[1].
Chemical Properties
Molecular Weight450.56
FormulaC23H26N6O2S
Cas No.1415925-18-6
SmilesCC(C)n1cc(-c2ccc3CCN(C)c3c2)c2c(NS(=O)(=O)c3ccn(C)n3)ccnc12
Relative Density.1.39 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (88.78 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.44 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2195 mL11.0973 mL22.1946 mL110.9730 mL
5 mM0.4439 mL2.2195 mL4.4389 mL22.1946 mL
10 mM0.2219 mL1.1097 mL2.2195 mL11.0973 mL
20 mM0.1110 mL0.5549 mL1.1097 mL5.5487 mL
50 mM0.0444 mL0.2219 mL0.4439 mL2.2195 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

ROSReactiveOxygenSpeciesReactive Oxygen SpeciesNOXNADPH OxidaseNADPHInhibitorinhibitGSK-2795039GSK2795039GSK 2795039apoptosisApoptosis
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