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MTI-31

Catalog No. T35343 CAS 1567915-38-1

Synonyms: MTI-31, LXI-15029

MTI-31 (LXI-15029) is a potent, orally active and highly selective inhibitor of mTORC1 and mTORC2. MTI-31 is selective for mTOR (Kd: 0.20 nM) versus PIK3CA, PIK3CB and PIK3G with <5,000 fold selectivity in mTOR binding assays. MTI-31 shows an IC50 of 39 nM for mTOR in LANCE assay of mTOR substrate phosphorylation with 100 μM ATP[1].

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MTI-31, CAS 1567915-38-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 293.00
5 mg	In stock	$ 622.00
10 mg	In stock	$ 976.00
25 mg	In stock	$ 1,450.00
50 mg	In stock	$ 1,960.00
100 mg	In stock	$ 2,630.00

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Purity: 99.76%

Biological Description

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Description	MTI-31 (LXI-15029) is a potent, orally active and highly selective inhibitor of mTORC1 and mTORC2. MTI-31 is selective for mTOR (Kd: 0.20 nM) versus PIK3CA, PIK3CB and PIK3G with >5,000 fold selectivity in mTOR binding assays. MTI-31 shows an IC50 of 39 nM for mTOR in LANCE assay of mTOR substrate phosphorylation with 100 μM ATP[1].
Targets&IC50	mTOR:0.2 nM(Kd)
In vitro	MTI-31 (0.01-100 μM) elicits a potent and more substantial inhibition of cell growth than that of Rapamycin[1]. Treatment with MTI-31 for 6 h demonstrates a dose-dependent inhibition of both the mTORC1 substrates P-S6K1(T389), P-S6(S235/6), P-4EBP1(T70) and mTORC2 substrate P-AKT(S473), achieving 50% inhibition at ≤0.12 μM in three representative tumor cell lines harboring mTOR pathway dysregulation (786-O renal, U87MG glioma and MDA-MB-453 breast)[1]. MTI-31-induced apoptosis requires mTORC2-regulated Bim- and GSK3 activity[1].
In vivo	MTI-31(5-40 mg/kg; orally) is efficacious in several tumor models harboring HER2+/PIK3CAmut and/or PTEN-deficiency exemplified by MDA-MB-453 and 786-O[1]. Treatment of tumor bearing nude mice with orally administered MTI-31 inhibits growth of H1975 tumors (25 mg/kg/d; orally) or U87MG tumors (30 mg/kg/d; orally)[2].

Synonyms	MTI-31, LXI-15029
Molecular Weight	474.55
Formula	C26H30N6O3
CAS No.	1567915-38-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 8.33 mg/mL (17.55 mM), Sonication and heating to 60℃ are recommended.

References and Literature

1. Jianchang Qian, et al. Oncotarget . 2016 Oct 11;7(41):67071-67086.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Kinase Inhibitor Library Glycolysis Compound Library Anti-Aging Compound Library Bioactive Compound Library Antidepressant Compound Library Anti-Liver Cancer Compound Library Anti-Obesity Compound Library Metabolism Compound Library

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Keywords

MTI-31 1567915-38-1 PI3K/Akt/mTOR signaling mTOR mTOR kinase inhibitor tissue factor LXI 15029 mTORC2 mTOR inhibitor Inhibitor EGFR mutant cancer mTOR-TF axis Mammalian target of Rapamycin MTI31 apoptosis inhibit MTI 31 mTORC1 lipid metabolism LXI-15029 LXI15029 tumor microenvironment inhibitor

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