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Kalii Dehydrographolidi Succinas (Alias: Dehydroandrographolide Succinate Potasium Salt, Ddhads)

Catalog No. T3667 Copy Product Info
Purity: 99.17%
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Kalii Dehydrographolidi Succinas (Dehydroandrographolide Succinate Potasium Salt) is a natural compound with anti-virus infection activity.

Kalii Dehydrographolidi Succinas

Copy Product Info
😃Good
Catalog No. T3667
Alias Dehydroandrographolide Succinate Potasium Salt, Ddhads

Kalii Dehydrographolidi Succinas (Dehydroandrographolide Succinate Potasium Salt) is a natural compound with anti-virus infection activity.

Kalii Dehydrographolidi Succinas
Cas No. 76958-99-1
Pack SizePriceUSA StockGlobal StockQuantity
5 mg$31In StockIn Stock
10 mg$48In StockIn Stock
25 mg$82In StockIn Stock
50 mg$118In StockIn Stock
100 mg$176In StockIn Stock
200 mg$259In StockIn Stock
1 mL x 10 mM (in DMSO)$51In StockIn Stock
In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Batch Information

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Purity:99.17%
Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
Kalii Dehydrographolidi Succinas (Dehydroandrographolide Succinate Potasium Salt) is a natural compound with anti-virus infection activity.
Kinase Assay
In vitro kinase assay is based on a filter binding assay, using the recombinant GST-fused kinase domains expressed in baculovirus and purified over glutathione-sepharose, γ-[33P]ATP as the phosphate donor, and poly(Glu:Tyr 4:1) peptide as the acceptor. Each GST-fused kinase is incubated under optimized buffer conditions [20 mM Tris-HCl buffer (pH 7.5), 1-3 mM MnCl2, 3-10 mM MgCl2, 3-8 μg/mL poly(Glu:Tyr 4:1), 0.25 mg/mL polyethylene glycol 20000, 8 μM ATP, 10 μM sodium vanadate, 1 mM DTT] and 0.2 μCi γ-33P ATP in a total volume of 30 μL in the presence or absence of a test substance for 10 min at ambient temperature. The reaction is stopped by adding 10 mL of 250 mM EDTA. Using a 384-well filter system, half the volume is transferred onto an Immobilon-polyvinylidene difluoride membrane. The membrane is then washed extensively and dried, and scintillation counting is performed. IC50s for compounds are calculated by linear regression analysis of the percentage inhibition[1].
SynonymsDehydroandrographolide Succinate Potasium Salt, Ddhads
Chemical Properties
Molecular Weight570.67
FormulaC28H35KO10
Cas No.76958-99-1
SmilesC[C@]12[C@@](CCC([C@H]2/C=C/C3=CCOC3=O)=C)([H])[C@@](C)([C@@H](CC1)OC(CCC([O-])=O)=O)COC(CCC(O)=O)=O.[K+]
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 9.42 mg/mL (16.51 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7523 mL8.7616 mL17.5233 mL87.6163 mL
5 mM0.3505 mL1.7523 mL3.5047 mL17.5233 mL
10 mM0.1752 mL0.8762 mL1.7523 mL8.7616 mL
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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