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Anti-Tyrosine Hydroxylase Antibody (4U295) (Synonyms: tyrosine hydroxylase)
Catalog No. TMAY-03508 Copy Product Info
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Anti-Tyrosine Hydroxylase Antibody (4U295) is a Rabbit antibody targeting Tyrosine Hydroxylase. Anti-Tyrosine Hydroxylase Antibody (4U295) can be used in ELISA,WB.
Anti-Tyrosine Hydroxylase Antibody (4U295)
Copy Product Info🥰Excellent
Catalog No. TMAY-03508
Synonyms tyrosine hydroxylase
Anti-Tyrosine Hydroxylase Antibody (4U295) is a Rabbit antibody targeting Tyrosine Hydroxylase. Anti-Tyrosine Hydroxylase Antibody (4U295) can be used in ELISA,WB.
Anti-Tyrosine Hydroxylase Antibody
(4U295)
(4U295)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 100 μL | $268 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-Tyrosine Hydroxylase Antibody (4U295) is a Rabbit antibody targeting Tyrosine Hydroxylase. Anti-Tyrosine Hydroxylase Antibody (4U295) can be used in ELISA,WB. |
| Synonyms | tyrosine hydroxylase |
| Ig Type | Rabbit IgG |
| Clone | 4U295 |
| Reactivity | Mouse |
| Specificity | Mouse Tyrosine Hydroxylase No cross-reactivity in ELISA with Human TPH1 |
| Verified Activity | Anti-TH rabbit monoclonal antibody at 1:500 dilution. -Lane A: PC12 Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:58 kDa. -Observed band size:63 kDa |
| Application | |
| Recommended Dose | WB: 1:500-1:2000; ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse TH / Tyrosine Hydroxylase (TMPY-02587; P24529; Pro2-Ser498). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Tyrosine hydroxylase (TH) is a rate-limiting enzyme in catecholamine synthesis. Tyrosine hydroxylase activity is modulated by protein-protein interactions with enzymes in the same pathway or the tetrahydrobiopterin pathway, structural proteins considered to be chaperones that mediate the neuron's oxidative state, and the protein that transfers dopamine into secretory vesicles. It is phosphorylated at serine (Ser) residues Ser8, Ser19, Ser31 and Ser40 in vitro. The phosphorylation of tyrosine hydroxylase at Ser19 or Ser8 has no direct effect on tyrosine hydroxylase activity. As tyrosine hydroxylase (TH) catalyses the formation of L-DOPA, the rate-limiting step in the biosynthesis of DA, the Parkinson's disease (PD) can be considered as a TH-deficiency syndrome of the striatum. A direct pathogenetic role of TH has also been suggested, as the enzyme is a source of reactive oxygen species (ROS) in vitro and a target for radical-mediated oxidative injury. Recently, it has been demonstrated that L-DOPA is effectively oxidized by mammalian Tyrosine hydroxylase in vitro, possibly contributing to the cytotoxic effects of DOPA. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Mouse TH / Tyrosine Hydroxylase protein (TMPY-02587) |
| Antigen Species | Mouse |
| Biology Area | Neurotransmitter Associated Enzymes |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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