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Difamilast

Name: Difamilast
Brand: TargetMol
SKU: T27172
Price: 63 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T27172Cas No. 937782-05-3

Difamilast is a selective inhibitor of phosphodiesterase-4 (PDE4) with particularly efficient inhibition of subtype B (IC50=11.2 nM).

Difamilast

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Purity: 99.64%

Catalog No. T27172Cas No. 937782-05-3

Difamilast is a selective inhibitor of phosphodiesterase-4 (PDE4) with particularly efficient inhibition of subtype B (IC50=11.2 nM).

Pack Size	Price	Availability
1 mg	$63	In Stock
5 mg	$152	In Stock
10 mg	$247	In Stock
25 mg	$455	In Stock
50 mg	$683	In Stock
1 mL x 10 mM (in DMSO)	$167	In Stock

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Batch Information

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Purity:99.64%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Difamilast is a selective inhibitor of phosphodiesterase-4 (PDE4) with particularly efficient inhibition of subtype B (IC50=11.2 nM).
Targets&IC50	PDE4B:11.2 nM
In vitro	Difamilast exerts inhibitory effects on PDE2[1].
In vivo	In relevant animal models of AD, Difamilast improves skin condition [3].

Chemical Properties

Molecular Weight	446.44
Formula	C₂₃H₂₄F₂N₂O₅
Cas No.	937782-05-3
Smiles	CCOc1ccccc1C(=O)NCc1coc(n1)-c1ccc(OC(F)F)c(OC(C)C)c1
Relative Density.	1.223 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (223.99 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2399 mL	11.1997 mL	22.3994 mL	111.9971 mL
5 mM	0.4480 mL	2.2399 mL	4.4799 mL	22.3994 mL
10 mM	0.2240 mL	1.1200 mL	2.2399 mL	11.1997 mL
20 mM	0.1120 mL	0.5600 mL	1.1200 mL	5.5999 mL
50 mM	0.0448 mL	0.2240 mL	0.4480 mL	2.2399 mL
100 mM	0.0224 mL	0.1120 mL	0.2240 mL	1.1200 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc