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Octenidine Dihydrochloride

Name: Octenidine Dihydrochloride
Brand: TargetMol
SKU: T3287
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3287Cas No. 70775-75-6

Octenidine is an antibiosis.

Octenidine Dihydrochloride

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Purity: 99.63%

Catalog No. T3287Cas No. 70775-75-6

Octenidine is an antibiosis.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$30	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.63%

Color:White

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Octenidine is an antibiosis.
In vitro	Octenidine at concentrations below 1.5 μM (0.94 μg/mL) results in over 99% reduction of the assessed microbial population within 15 minutes. Among the tested organisms, Staphylococcus epidermidis exhibits the highest susceptibility, whereas E. coli and C. Albicans show the lowest susceptibility[1].
In vivo	Octenidine hydrochloride (OCT) demonstrates sustained antimicrobial activity upon application to the skin of cynomolgus monkeys' hands and feet. Aqueous octenidine effectively diminishes resident microflora by 90 to 99.98% at concentrations ranging from 0.2 to 1.6%[1]. Moreover, a significant reduction in plaque score on buccal tooth surfaces was observed following daily topical applications of 1% solutions of octenidine and chlorhexidine for seven days, with octenidine proving to be more effective than chlorhexidine[2].
Kinase Assay	The bactericidal activities of OCT and CHG against Staphylococcus aureus are measured by exposing cultures to several different concentrations of each compound for various lengths of time. OCT is diluted from the 5 mM stock solution and tested in phosphate buffer at levels ranging from 0.5 to 5.0 FsM. The test is begun by adding the bacterial culture to the test solution containing OCT or CHG; samples are taken at 5, 15, 30, and 60 min afterward. The inoculum size is approximately 106 CFU/mL[1].

Chemical Properties

Molecular Weight	623.82
Formula	C₃₆H₆₄Cl₂N₄
Cas No.	70775-75-6
Smiles	[Cl-].[Cl-].CCCCCCCCNc1cc[n+](CCCCCCCCCC[n+]2ccc(NCCCCCCCC)cc2)cc1
Relative Density.	1.046 g/cm3 at 20℃

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 9.62 mg/mL (15.42 mM), Sonication is recommended.

H2O: 50 mg/mL (80.15 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (1.6 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.6030 mL	8.0151 mL	16.0303 mL	80.1513 mL
5 mM	0.3206 mL	1.6030 mL	3.2061 mL	16.0303 mL
10 mM	0.1603 mL	0.8015 mL	1.6030 mL	8.0151 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.0802 mL	0.4008 mL	0.8015 mL	4.0076 mL
50 mM	0.0321 mL	0.1603 mL	0.3206 mL	1.6030 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc