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3,5,7,3′,4′-Pentamethoxyflavone

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Catalog No. TN2121Cas No. 1247-97-8
Alias Quercetin 3,5,7,3,4-pentamethyl ether

3,5,7,3′,4′-Pentamethoxyflavone (Quercetin 3,5,7,3,4-pentamethyl ether) is a natural product that induces adipogenesis in 3T3-L1 preadipocytes by regulating transcription factors during the early stages of differentiation.

3,5,7,3′,4′-Pentamethoxyflavone

3,5,7,3′,4′-Pentamethoxyflavone

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🥰Excellent
Purity: 99.73%
Catalog No. TN2121Alias Quercetin 3,5,7,3,4-pentamethyl etherCas No. 1247-97-8
3,5,7,3′,4′-Pentamethoxyflavone (Quercetin 3,5,7,3,4-pentamethyl ether) is a natural product that induces adipogenesis in 3T3-L1 preadipocytes by regulating transcription factors during the early stages of differentiation.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$53In StockIn Stock
2 mg$75In StockIn Stock
5 mg$123In StockIn Stock
10 mg$198In StockIn Stock
1 mL x 10 mM (in DMSO)$136In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.73%
Appearance:Solid
Color:White
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Product Introduction

3,5,7,3′,4′-Pentamethoxyflavone AI Summary
3,5,7,3′,4′-Pentamethoxyflavone has demonstrated diverse bioactivities and promising pharmacological potential across multiple assays. It acts as a maxi-K channel opener with 94.6% activity at 20 µM and shows significant phosphodiesterase inhibitory activity, particularly cAMP and cGMP flow in rat brain cytosolic and particulate extracts, respectively. It also exhibits cytotoxicity against human KB cells with an ED50 of 25.0 µg/ml and promotes adipogenesis and glucose uptake in mouse 3T3L1 cells. Additionally, 3,5,7,3′,4′-Pentamethoxyflavone shows potential as a multidrug resistance modulator, inhibiting MRP1, p-glycoprotein, and BCRP, possibly aiding in cancer treatments. It also displays activities as an inhibitor of various enzymes and pathways including JMJD2E, TDP1, ALDH1A1, the ERK signaling pathway, and the Menin-MLL interaction, among others. Furthermore, 3,5,7,3′,4′-Pentamethoxyflavone has pharmacokinetic properties indicative of moderate to high oral bioavailability and rapid clearance in Wistar rats. It exhibits low bioavailability in excretion but has broad tissue distribution. Notably, 3,5,7,3′,4′-Pentamethoxyflavone has potential as a thrombin inhibitor and shows weak inhibition of Influenza A virus polymerase activity. Finally, it has antioxidant properties and demonstrates antiproliferative effects on human MDA-MB-231 cells..
Note: Summary generated by AI. Data source: ChEMBL
Bioactivity
Description
3,5,7,3′,4′-Pentamethoxyflavone (Quercetin 3,5,7,3,4-pentamethyl ether) is a natural product that induces adipogenesis in 3T3-L1 preadipocytes by regulating transcription factors during the early stages of differentiation.
SynonymsQuercetin 3,5,7,3,4-pentamethyl ether
Chemical Properties
Molecular Weight372.37
FormulaC20H20O7
Cas No.1247-97-8
SmilesCOc1cc(OC)c2c(c1)oc(-c1ccc(OC)c(OC)c1)c(OC)c2=O
Relative Density.1.29 g/cm3
Storage & Solubility Information
Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 30 mg/mL (80.57 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.37 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6855 mL13.4275 mL26.8550 mL134.2750 mL
5 mM0.5371 mL2.6855 mL5.3710 mL26.8550 mL
10 mM0.2686 mL1.3428 mL2.6855 mL13.4275 mL
20 mM0.1343 mL0.6714 mL1.3428 mL6.7138 mL
50 mM0.0537 mL0.2686 mL0.5371 mL2.6855 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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