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SP 600125, negative control

🥰Excellent
Catalog No. T38260Cas No. 54642-23-8
Alias JNK Inhibitor II, negative control

SP 600125, negative control is a methylated analog of SP 600125 and can be used as a negative control for SP 600125. SP 600125, negative control inhibits DTP3 and GADD45β/MKK7 (growth arrest and DNA damage-inducible β/mediator-activated protein kinase kinase kinase 7) and is capable of restoring activation.The IC50s of SP 600125, negative control against JNK2 and JNK3 were 18 and 24 μM, respectively.

SP 600125, negative control

SP 600125, negative control

🥰Excellent
Catalog No. T38260Alias JNK Inhibitor II, negative controlCas No. 54642-23-8
SP 600125, negative control is a methylated analog of SP 600125 and can be used as a negative control for SP 600125. SP 600125, negative control inhibits DTP3 and GADD45β/MKK7 (growth arrest and DNA damage-inducible β/mediator-activated protein kinase kinase kinase 7) and is capable of restoring activation.The IC50s of SP 600125, negative control against JNK2 and JNK3 were 18 and 24 μM, respectively.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$38In StockIn Stock
25 mg$77In StockIn Stock
50 mg$116In StockIn Stock
100 mg$172In StockIn Stock
500 mg$418-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:≥98%
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Product Introduction

Bioactivity
Description
SP 600125, negative control is a methylated analog of SP 600125 and can be used as a negative control for SP 600125. SP 600125, negative control inhibits DTP3 and GADD45β/MKK7 (growth arrest and DNA damage-inducible β/mediator-activated protein kinase kinase kinase 7) and is capable of restoring activation.The IC50s of SP 600125, negative control against JNK2 and JNK3 were 18 and 24 μM, respectively.
Targets&IC50
TrkB:0.899 µM
SynonymsJNK Inhibitor II, negative control
Chemical Properties
Molecular Weight234.25
FormulaC15H10N2O
Cas No.54642-23-8
SmilesO=C1C=2C=3C(C=4C1=CC=CC4)=NN(C)C3C=CC2
ColorYellow
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 9 mg/mL (38.42 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.2689 mL21.3447 mL42.6894 mL213.4472 mL
5 mM0.8538 mL4.2689 mL8.5379 mL42.6894 mL
10 mM0.4269 mL2.1345 mL4.2689 mL21.3447 mL
20 mM0.2134 mL1.0672 mL2.1345 mL10.6724 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

SP 600125, negative controlJNK3JNK2GADD45β/MKK7
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