Shopping Cart

Your shopping cart is currently empty

AR-9281

Name: AR-9281
Brand: TargetMol
SKU: T14315
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T14315Cas No. 913548-29-5

Alias APAU

AR-9281 (APAU) is a potent and selective inhibitor of soluble epoxide hydrolase (s-EH) potentially for the treatment of hypertension and type 2 diabetes

AR-9281

Copy Product Info

😃Good

Purity: 99.79%

Catalog No. T14315Alias APAUCas No. 913548-29-5

AR-9281 (APAU) is a potent and selective inhibitor of soluble epoxide hydrolase (s-EH) potentially for the treatment of hypertension and type 2 diabetes

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$29	In Stock	In Stock
5 mg	$48	In Stock	In Stock
10 mg	$77	In Stock	In Stock
25 mg	$158	In Stock	In Stock
50 mg	$251	In Stock	In Stock
100 mg	$397	In Stock	In Stock
200 mg	$578	-	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.79%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

AR-9281 AI Summary

AR-9281 is a potent inhibitor of soluble epoxide hydrolase (sEH) across various species, including humans and rodents. It demonstrates high inhibitory activity with IC50 values of 7.0 nM in humans, 8.0 nM in recombinant human sEH, and 1.7 nM in mouse recombinant sEH. In different animal models, it shows variable inhibitory potencies, including 9.0 nM in mice, 6.0 nM in rats, and 2.0 nM in hamsters, but much lower activity against cat and dog sEH with IC50 values of 450.0 nM and 500.0 nM respectively. The compound has significant pharmacokinetic properties, exhibiting an AUC of 197.0 ng·hr·mL-1 in dogs at an oral dose of 0.3 mg/kg. AR-9281 demonstrates good oral bioavailability in cynomolgus monkeys with a bioavailability factor (F) of 25.0% and in rats with an F value of 100.0%. It also exhibits a high solubility in various buffer solutions, high permeability in Caco-2 cells, and minimal inhibition of human ERG channels. The compound shows antidiabetic activity in diet-induced obese (DIO) mice, as well as antihypertensive effects in spontaneously hypertensive rats. It possesses a good metabolic stability in liver microsomes from humans, mice, and rats, maintaining significant amounts of the parent compound over 60 minutes. Additionally, AR-9281 has a measured Cmax and AUC of 30.0 nM and 58.46 ng·hr·mL-1 respectively in Swiss Webster mice after oral administration at 0.3 mg/kg. These properties highlight its potential for modulating inflammatory and metabolic pathways involving lipid signaling molecules..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	AR-9281 (APAU) is a potent and selective inhibitor of soluble epoxide hydrolase (s-EH) potentially for the treatment of hypertension and type 2 diabetes
Synonyms	APAU

Chemical Properties

Molecular Weight	319.44
Formula	C₁₈H₂₉N₃O₂
Cas No.	913548-29-5
Smiles	CC(=O)N1CCC(CC1)NC(=O)NC12CC3CC(CC(C3)C1)C2
Relative Density.	1.19 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (78.26 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.26 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1305 mL	15.6524 mL	31.3048 mL	156.5239 mL
5 mM	0.6261 mL	3.1305 mL	6.2610 mL	31.3048 mL
10 mM	0.3130 mL	1.5652 mL	3.1305 mL	15.6524 mL
20 mM	0.1565 mL	0.7826 mL	1.5652 mL	7.8262 mL
50 mM	0.0626 mL	0.3130 mL	0.6261 mL	3.1305 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc