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5-Desmethylsinensetin
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Catalog No. TN6930Cas No. 21763-80-4
5-desmethylsinensetin is a natural product isolated from Stevia satureiifolia var. satureiifolia with antiprotozoal activity, 5-desmethylsinensetin shows IC50 values of 0.4 μg/mL on T. cruzi epimastigotes and 75.1 μg/mL on trypomastigotes, respectively.
5-Desmethylsinensetin
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Purity: 99.95%
Catalog No. TN6930Cas No. 21763-80-4
5-desmethylsinensetin is a natural product isolated from Stevia satureiifolia var. satureiifolia with antiprotozoal activity, 5-desmethylsinensetin shows IC50 values of 0.4 μg/mL on T. cruzi epimastigotes and 75.1 μg/mL on trypomastigotes, respectively.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $84 | - | In Stock | |
| 2 mg | $123 | - | In Stock | |
| 5 mg | $198 | - | In Stock | |
| 10 mg | $297 | - | In Stock | |
| 25 mg | $515 | - | In Stock | |
| 50 mg | Preferential | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.95%
Appearance:Solid
Color:White to Yellow
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Product Introduction
5-Desmethylsinensetin AI Summary
5-Desmethylsinensetin exhibits a range of bioactivities, including antiproliferative activity against HL60 cells with an IC50 value greater than 100,000.0 nM and apoptotic activity with an AC50 value above 100,000.0 nM. It has antimicrobial properties, with a MIC of 125.0 µg/mL and MBC of 250.0 µg/mL against Pseudomonas aeruginosa, and a MIC of 250.0 µg/mL and MBC of 500.0 µg/mL against Escherichia coli. The compound also exhibits cytotoxic effects on human KB cells (ED50 > 100.0 µg/mL), HeLa cells (IC50 = 8100.0 nM), and MCF7 cells (IC50 = 10300.0 nM). Additionally, 5-Desmethylsinensetin shows potent antioxidant activity with an ED50 less than 100.0 µM in DPPH radical scavenging assays. It acts as an agonist at the human delta opioid receptor and displays displacement activity at CB1, CB2, mu, and kappa opioid receptors. Moreover, it exhibits strong inhibitory activity against several cytochrome P450 enzymes, particularly CYP1A1, CYP1A2, and CYP1B1, with significant inhibition also observed for CYP3A4 and moderate effects on CYP2D6, CYP2C9, and CYP2C19..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 5-desmethylsinensetin is a natural product isolated from Stevia satureiifolia var. satureiifolia with antiprotozoal activity, 5-desmethylsinensetin shows IC50 values of 0.4 μg/mL on T. cruzi epimastigotes and 75.1 μg/mL on trypomastigotes, respectively. |
| Molecular Weight | 358.34 |
| Formula | C19H18O7 |
| Cas No. | 21763-80-4 |
| Smiles | COc1ccc(cc1OC)-c1cc(=O)c2c(O)c(OC)c(OC)cc2o1 |
| Relative Density. | 1.309g/cm3 |
| Storage | keep away from direct sunlight,keep away from moisture,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 13.25 mg/mL (36.98 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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