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Anti-PSENEN Antibody (3P624)
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Catalog No. TMAC-03154
Alias PSENEN, Presenilin enhancer protein 2, PEN2, Gamma-secretase subunit PEN-2
Anti-PSENEN Antibody (3P624) is a Rabbit antibody targeting PSENEN. Anti-PSENEN Antibody (3P624) can be used in FCM,ICC,IHC,WB.
Anti-PSENEN Antibody (3P624)
Anti-PSENEN Antibody (3P624)
😃Good
Catalog No. TMAC-03154Alias PSENEN, Presenilin enhancer protein 2, PEN2, Gamma-secretase subunit PEN-2
Anti-PSENEN Antibody (3P624) is a Rabbit antibody targeting PSENEN. Anti-PSENEN Antibody (3P624) can be used in FCM,ICC,IHC,WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $296 | 7-10 days | 7-10 days | |
| 100 μL | $496 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-PSENEN Antibody (3P624) is a Rabbit antibody targeting PSENEN. Anti-PSENEN Antibody (3P624) can be used in FCM,ICC,IHC,WB. |
| Synonyms | PSENEN, Presenilin enhancer protein 2, PEN2, Gamma-secretase subunit PEN-2 |
| Ig Type | IgG |
| Clone | 3P624 |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Western blot analysis of PEN2 on mouse spleen tissue lysate using anti-PEN2 antibody at 1/2,000 dilution. 2. Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-PEN2 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-PEN2 antibody. Counter stained with hematoxylin. 4. Immunohistochemical analysis of paraffin-embedded rat cerebellum tissue using anti-PEN2 antibody. Counter stained with hematoxylin. 5. Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti-PEN2 antibody. Counter stained with hematoxylin. 6. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-PEN2 antibody. Counter stained with hematoxylin. 7. ICC staining PEN2 in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 8. ICC staining PEN2 in SH-SY-5Y cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 9. Flow cytometric analysis of A549 cells with PEN2 antibody at 1/100 dilution (purple) compared with an unlabelled control (cells without incubation with primary antibody; yellow). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody.          |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC: 1:50-200; ICC: 1:50-200; FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | Four proteins comprise the gamma-secretase complex: presenilin, nicastrin, aph-1, and PEN-2. Together, these proteins mediate cell surface signaling pathways for a variety of type I membrane proteins, notably amyloid-beta precursor protein, a protein implicated in the development of Alzheimer's disease, via intramembrane proteolysis. The proteins assemble into a proteolytically active complex in the golgi/trans-golgi network (TGN) compartments. Assembly leads to autocleavage of presenilin into two subunits to create the active site of gamma-secretase, an important step in understanding the mechanisms involved in the etiology and possible treatment of Alzheimer's disease. |
| Conjucates | Unconjugated |
| Immunogen | A synthesized peptide: C-terminal human PEN2 |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Theoretical: 12 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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