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Anti-EphB3 Antibody (8R580)
😃Good
Catalog No. TMAY-03361
Anti-EphB3 Antibody (8R580) is a Rabbit antibody targeting EphB3. Anti-EphB3 Antibody (8R580) can be used in FCM.
Anti-EphB3 Antibody (8R580)
Anti-EphB3 Antibody (8R580)
😃Good
Catalog No. TMAY-03361
Anti-EphB3 Antibody (8R580) is a Rabbit antibody targeting EphB3. Anti-EphB3 Antibody (8R580) can be used in FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-EphB3 Antibody (8R580) is a Rabbit antibody targeting EphB3. Anti-EphB3 Antibody (8R580) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 8R580 |
| Reactivity | Mouse |
| Verified Activity | Flow cytometric analysis of Mouse EphB3 expression on CoLo205 cells. Cells were stained with purified anti-Mouse EphB3, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse EphB3 / HEK2 / Eph Receptor B3 (rM EphB3 / HEK2 / Eph Receptor B3; TMPY-01784; NP_034273.1; Met1-Thr537). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Ephrin type-B receptor 3, also known as EphB3 or HEK2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induces various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. EphB receptor tyrosine kinases are enriched at synapses, suggesting that these receptors play a role in synapse formation or function. We find that EphrinB binding to EphB induces a direct interaction of EphB with NMDA-type glutamate receptors. This interaction occurs at the cell surface and is mediated by the extracellular regions of the two receptors, but does not require the kinase activity of EphB. |
| Conjucates | Unconjugated |
| Others Formats | APC/PE |
| Antibody Types Available | 3 |
| Immunogen | Recombinant Mouse EphB3 / HEK2 / Eph Receptor B3 Protein (TMPY-01784) |
| Antigen Species | Mouse |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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