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Swainsonine

Name: Swainsonine
Brand: TargetMol
SKU: TN2344
Rating: 4.5 (1 reviews)

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Catalog No. TN2344Cas No. 72741-87-8

Alias Tridolgosir

Swainsonine (Tridolgosir) is an alkaloid isolated from Astragalus membranaceus and is a potent and reversible inhibitor of alpha-mannosidase. swainsonine has antitumour activity and induces apoptosis and cell cycle arrest in the G2/M phase.

Swainsonine

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Catalog No. TN2344Alias TridolgosirCas No. 72741-87-8

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	Swainsonine (Tridolgosir) is an alkaloid isolated from Astragalus membranaceus and is a potent and reversible inhibitor of alpha-mannosidase. swainsonine has antitumour activity and induces apoptosis and cell cycle arrest in the G2/M phase.
Targets&IC50	Golgi α-mannosidase II:0.2 μM, Lysosomal α-mannosidase:0.2 μM
In vitro	Swainsonine (0-40 μM ; 12 h) showed anti-proliferative activity in U251 and LN444 cells.[2] Swainsonine (30 μM ; 12 h) induced apoptosis and cell cycle arrest in G2/M phase and decreased the expression of CyclinD1 and CDK4 protein levels and increased the expression of p16 protein level.[2] Swainsonine (30 μM ; 12 h) reduces glioma cell migration and invasion.[2]
In vivo	Swainsonine (1 mg/kg ; intraperitoneal injection ; twice daily for 10 days) and cisplatin increased the antitumor efficacy in mice.[3]
Synonyms	Tridolgosir

Chemical Properties

Molecular Weight	173.21
Formula	C₈H₁₅NO₃
Cas No.	72741-87-8
Smiles	OC1CN2CCCC(O)C2C1O
Relative Density.	1.38 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 9 mg/mL (51.96 mM), Sonication and heating are recommended.

DMSO: 9 mg/mL (51.96 mM), Sonication and heating are recommended.

H2O: 3.2 mg/mL (18.47 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.7733 mL	28.8667 mL	57.7334 mL	288.6669 mL
5 mM	1.1547 mL	5.7733 mL	11.5467 mL	57.7334 mL
10 mM	0.5773 mL	2.8867 mL	5.7733 mL	28.8667 mL

Ethanol/DMSO

	1mg	5mg	10mg	50mg
20 mM	0.2887 mL	1.4433 mL	2.8867 mL	14.4333 mL
50 mM	0.1155 mL	0.5773 mL	1.1547 mL	5.7733 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc