Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Polymyxin B, an antibiotic, combats Gram-negative infections through high-affinity binding to the bacterial wall's lipopolysaccharides (LPS), neutralizing endotoxin effects and inducing bacterial cell death by enhancing permeability. It is utilized in endotoxemia research [1] [3].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | Inquiry | $ 34.00 |
Description | Polymyxin B, an antibiotic, combats Gram-negative infections through high-affinity binding to the bacterial wall's lipopolysaccharides (LPS), neutralizing endotoxin effects and inducing bacterial cell death by enhancing permeability. It is utilized in endotoxemia research [1] [3]. |
In vitro | Polymyxin B (10 μg/mL, 6 hours) reduced the production of TNF-α and IL-10 in human peripheral blood mononuclear cells (PBMCs) [3]. |
In vivo | Polymyxin B, administered intravenously at dosages ranging from 5-20 mg/kg once daily for seven days, achieved nephrotoxicity endpoints in a Sprague-Dawley rat model at a concentration of 20 mg/kg, with no such endpoints observed at 5 mg/kg [2]. |
Molecular Weight | N/A |
CAS No. | 1404-26-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Polymyxin B 1404-26-8 inhibitor inhibit