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Guanabenz hydrochloride

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Catalog No. T21957Cas No. 23113-43-1
Alias NE56490

Guanabenz hydrochloride (NE56490) is an orally active α2-adrenoceptor agonist with hypotensive effects.

Guanabenz hydrochloride
Other Forms of Guanabenz hydrochloride:

Guanabenz hydrochloride

🥰Excellent
Purity: 99.45%
Catalog No. T21957Alias NE56490Cas No. 23113-43-1
Guanabenz hydrochloride (NE56490) is an orally active α2-adrenoceptor agonist with hypotensive effects.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 mg$38In StockIn Stock
100 mg$73In StockIn Stock
200 mg$107In StockIn Stock
500 mg$178In StockIn Stock
1 mL x 10 mM (in DMSO)$29In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.45%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
Guanabenz hydrochloride (NE56490) is an orally active α2-adrenoceptor agonist with hypotensive effects.
In vivo
Maximum concentrations of guanabenz hydrochloride in plasma (1.2 to 5.2 ng/ml) reached 2 to 5 hours after administration of capsules containing 16 or 32 mg of 14C-labelled guanabenz hydrochloride. Guanabenz hydrochloride was 90% bound to human plasma proteins. Guanabenz hydrochloride competed for imidazoline I2-binding sites in brown adipose tissue with Ki of 97 nM.
SynonymsNE56490
Chemical Properties
Molecular Weight267.54
FormulaC8H9Cl3N4
Cas No.23113-43-1
SmilesClC1=C(C=NNC(N)=N)C(Cl)=CC=C1.[H]Cl
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 55 mg/mL (205.58 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.48 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.7378 mL18.6888 mL37.3776 mL186.8879 mL
5 mM0.7476 mL3.7378 mL7.4755 mL37.3776 mL
10 mM0.3738 mL1.8689 mL3.7378 mL18.6888 mL
20 mM0.1869 mL0.9344 mL1.8689 mL9.3444 mL
50 mM0.0748 mL0.3738 mL0.7476 mL3.7378 mL
100 mM0.0374 mL0.1869 mL0.3738 mL1.8689 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

α2-adrenoceptorParasiteNE-56490NE 56490Inhibitorinhibithigh blood pressureGuanabenz hydrochlorideGuanabenz HydrochlorideGuanabenzBeta ReceptorantiparasiticantihypertensiveAdrenergicReceptorAdrenergic Receptor
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