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Litifilimab
(Synonyms: BIIB059, BIIB 059) Copy Product Info
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Synonyms: BIIB059, BIIB 059
Catalog No. T78329 Copy Product Info
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Litifilimab (BIIB059) is a humanizedantibody targeting the plasma cell-like dendritic cell specific antigen (BDCA2) and C-type lectin structural domain family 4, member C (CLEC4C) for the study of cutaneous lupus erythematosus.
Cas No. 2407378-48-5
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $173 | - | In Stock | |
| 5 mg | $365 | - | In Stock | |
| 10 mg | $582 | - | In Stock | |
| 25 mg | $863 | - | In Stock | |
| 50 mg | Preferential | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:97.4% (SDS-PAGE); 99.1% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Litifilimab (BIIB059) is a humanizedantibody targeting the plasma cell-like dendritic cell specific antigen (BDCA2) and C-type lectin structural domain family 4, member C (CLEC4C) for the study of cutaneous lupus erythematosus. |
| In vivo | Methods: Macaques were administered Litifilimab via intravenous injection at single doses of 1 and 10 mg/kg and multiple doses of 5 mg/kg, and via subcutaneous injection at doses of 0.2 and 7.5 mg/kg. Plasma drug concentrations were measured to obtain PK data; the surface density of the BDCA2 receptor on plasma-like dendritic cells (pDCs) was measured to obtain PD data. Results: Litifilimab rapidly and completely downregulated BDCA2 expression on the surface of pDCs in crab-eating macaques, and the time to receptor recovery correlated with the drug clearance rate. [1] |
| Synonyms | BIIB059, BIIB 059 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | CLEC4C |
| Molecular Weight | 145.23 kDa |
| Cas No. | 2407378-48-5 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: Litifilimab chemical structure | Litifilimab in vivo | Litifilimab molecular weight
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