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Myricitrin

Name: Myricitrin
Brand: TargetMol
SKU: T2757
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2757Cas No. 17912-87-7

Alias Myricitrine, Myricetrin

Myricitrin (Myricitrine), a flavonoid compound isolated from the root bark of Myrica cerifera, exerts antinociceptive effects.

Myricitrin

🥰Excellent

Purity: 99.72%

Catalog No. T2757Alias Myricitrine, MyricetrinCas No. 17912-87-7

Myricitrin (Myricitrine), a flavonoid compound isolated from the root bark of Myrica cerifera, exerts antinociceptive effects.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
20 mg	$50	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.72%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Myricitrin (Myricitrine), a flavonoid compound isolated from the root bark of Myrica cerifera, exerts antinociceptive effects.
In vitro	In mice, Myricitrin (10/30 mg/kg, i.p.) blocks apomorphine-induced stereotypy and climbing behaviors, while also prolonging the hindlimb withdrawal time.
In vivo	In rodent models of chemical and mechanical pain, Flurbiprofen activates protein kinase Cα and PKCε, while Myricitrin blocks this action, thereby exerting a significant analgesic effect. The pain-relief mechanism of Myricitrin is attributed to a decrease in calcium ion influx and the opening of voltage-dependent and small-conductance calcium-activated potassium (K+) channels. Additionally, Myricitrin inhibits the expression of the p53 gene, which leads to the activation of caspase-3 and the MAPK signaling pathway, while altering the expression pattern of anti-apoptotic and pro-apoptotic genes. Consequently, this reduces H₂O₂-induced apoptosis in vascular endothelial cells.
Synonyms	Myricitrine, Myricetrin

Chemical Properties

Molecular Weight	464.38
Formula	C₂₁H₂₀O₁₂
Cas No.	17912-87-7
Smiles	C[C@@H]1O[C@@H](Oc2c(oc3cc(O)cc(O)c3c2=O)-c2cc(O)c(O)c(O)c2)[C@H](O)[C@H](O)[C@H]1O
Relative Density.	1.88 g/cm3
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 86 mg/mL (185.19 mM), Sonication is recommended.

Ethanol: 1 mg/mL (2.15 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 3.3 mg/mL (7.11 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1534 mL	10.7670 mL	21.5341 mL	107.6704 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.4307 mL	2.1534 mL	4.3068 mL	21.5341 mL
10 mM	0.2153 mL	1.0767 mL	2.1534 mL	10.7670 mL
20 mM	0.1077 mL	0.5384 mL	1.0767 mL	5.3835 mL
50 mM	0.0431 mL	0.2153 mL	0.4307 mL	2.1534 mL
100 mM	0.0215 mL	0.1077 mL	0.2153 mL	1.0767 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc